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Spermidine: Difference between revisions
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Spermidine is a naturally occurring biogenic polyamine, synthesized from the amino acid ornithine through the action of the enzyme ornithine decarboxylase (ODC). It is involved in various fundamental biological processes, including DNA stability, RNA transcription, translation, enzyme function, and cell proliferation. As a cellular polyamine, spermidine is essential for both normal and neoplastic tissue growth and is found in all eukaryotic cells. | Spermidine is a naturally occurring biogenic polyamine, synthesized from the amino acid ornithine through the action of the enzyme ornithine decarboxylase (ODC). It is involved in various fundamental biological processes, including DNA stability, RNA transcription, translation, enzyme function, and cell proliferation. As a cellular polyamine, spermidine is essential for both normal and neoplastic tissue growth and is found in all eukaryotic cells. | ||
== Dietary Sources == | ==Dietary Sources== | ||
Spermidine is | Good dietary sources of spermidine are aged cheese, mushrooms, soy products, legumes, corn, and whole grains.<ref name="Ali2011">{{cite journal | doi = 10.3402/fnr.v55i0.5572 | title = Polyamines in foods: development of a food database | year = 2011 | last1 = Ali | first1 = Mohamed Atiya | last2 = Poortvliet | first2 = Eric | last3 = Strömberg | first3 = Roger | last4 = Yngve | first4 = Agneta | journal = Food Nutr Res. | volume = 55 | pages = 5572 | pmid = 21249159 | pmc=3022763}}</ref> Spermidine is plentiful in a Mediterranean diet.<ref name="pmid29371440" /> | ||
For comparison: The spermidine content in human seminal plasma varies between approx. 15 and 50 mg/L (mean 31 mg/L).<ref>{{citation|editor-surname1= Ciba-Geigy|periodical=Wissenschaftliche Tabellen Geigy|title=Sperma|edition=8|volume=Teilband Körperflüssigkeiten|publisher=CIBA-GEIGY Limited|location=Basel|at=pp. 181-189|date=1977|language=de | For comparison: The spermidine content in human seminal plasma varies between approx. 15 and 50 mg/L (mean 31 mg/L).<ref>{{citation|editor-surname1= Ciba-Geigy|periodical=Wissenschaftliche Tabellen Geigy|title=Sperma|edition=8|volume=Teilband Körperflüssigkeiten|publisher=CIBA-GEIGY Limited|location=Basel|at=pp. 181-189|date=1977|language=de | ||
}}</ref> | }}</ref> | ||
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|Wheat germ | |Wheat germ | ||
|243 | |243 | ||
|<ref name=":0" /> | |<ref name=":0">{{cite web|url=http://www.oryza.co.jp/html/english/pdf/polyamine_vol.2.pdf|title=Brochure on Polyamines, rev. 2|publisher=Oryza Oil & Fat Chemocial Co., Ltd.|location=Japan|date=2011-12-26|access-date=2013-11-06}}</ref> | ||
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| Soybean, dried || 207 || Japanese <ref name=Ali2011/> | | Soybean, dried || 207 || Japanese <ref name=Ali2011/> | ||
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| Broccoli (cooked) || 25 || <ref name="Ali2011" /> | | Broccoli (cooked) || 25 || <ref name="Ali2011" /> | ||
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== Spermidine and Longevity == | == Spermidine and Longevity == | ||
Research has identified a significant correlation between the exogenous supplementation of spermidine and increased lifespan in several model organisms such as yeast, worms, flies, and mice. The longevity-promoting properties of spermidine are primarily attributed to its role in inducing autophagy. | Research has identified a significant correlation between the exogenous supplementation of spermidine and increased lifespan in several model organisms such as yeast, worms, flies, and mice. The longevity-promoting properties of spermidine are primarily attributed to its role in inducing autophagy. | ||