2,851
edits
Creatine: Difference between revisions
→Antidepressive Effects
| Line 61: | Line 61: | ||
Robust evidence highlights the significance of creatine on cognitive function, particularly observed in individuals with creatine deficient syndromes known to deplete brain creatine stores. Creatine deficiency syndrome is marked by mental and developmental disorders, including learning delays and seizures. Notably, these symptoms are, to some extent, reversed by creatine supplementation. Human studies have yielded mixed results. While some studies have discovered benefits on cognitive functioning, others found no such effects, as comprehensively reviewed by Roschel and colleagues in 2022. {{#pmid:35267907|pmid35267907}} | Robust evidence highlights the significance of creatine on cognitive function, particularly observed in individuals with creatine deficient syndromes known to deplete brain creatine stores. Creatine deficiency syndrome is marked by mental and developmental disorders, including learning delays and seizures. Notably, these symptoms are, to some extent, reversed by creatine supplementation. Human studies have yielded mixed results. While some studies have discovered benefits on cognitive functioning, others found no such effects, as comprehensively reviewed by Roschel and colleagues in 2022. {{#pmid:35267907|pmid35267907}} | ||
===Chronic Fatigue Syndrome=== | |||
Chronic fatigue syndrome (CFS), also known as post-viral fatigue syndrome (PFS) or myalgic encephalomyelitis (ME), is associated with persistent fatigue and other symptoms like muscle pains and cognitive disorders. The exact cause of these conditions is unknown, but recent studies have shown interest in creatine's potential to enhance functional capacity in affected individuals. Some evidence suggests that impaired creatine metabolism may play a role in CFS-related diseases. {{#pmid:33572884|pmid33572884}} | |||
Several studies explored creatine or creatine-related compounds' impact on patient outcomes in CFS conditions. For instance, creatine supplementation led to improvements in depression symptoms, pain measures, and quality of life in certain patients. Another study showed significant improvements in severity markers of fibromyalgia, disability, pain, sleep quality, and overall life quality with creatine supplementation, although these improvements reverted after stopping the therapy. Creatine supplementation also showed potential in increasing muscle function in fibromyalgia patients. Additionally, GAA supplementation positively impacted creatine metabolism and work capacity in women with CFS, albeit without significantly affecting general fatigue symptoms. {{#pmid:33572884|pmid33572884}} | |||
The findings from these studies suggest that creatine and/or GAA may offer some therapeutic benefits for patients with CFS, ME, or fibromyalgia by improving functional capacity. However, more research is needed to confirm these effects and understand creatine's role better in managing chronic fatigue-related syndromes. {{#pmid:33572884|pmid33572884}} | |||
=== Antidepressive Effects === | === Antidepressive Effects === | ||
There have been suggestions since the early 1980s that creatine metabolism or availability might have antidepressive effects, based on numerous studies. Further investigations have assessed how creatine or its precursors like [[S-Adenosylmethionine (SAMe)|S-adenosyl-L-methionine (SAMe)]] and [[Guanidinoacetate (GAA)|guanidinoacetate (GAA)]], influence brain phosphagen levels, depression markers, or the effectiveness of antidepressant medications. For instance, SAMe has been found to be a viable treatment for clinical depression. In one study, SAMe supplementation led to increased brain creatine and phosphocreatine (PCr) levels, with a more pronounced effect in women compared to men. {{#pmid:33572884|pmid33572884}} | There have been suggestions since the early 1980s that creatine metabolism or availability might have antidepressive effects, based on numerous studies. Further investigations have assessed how creatine or its precursors like [[S-Adenosylmethionine (SAMe)|S-adenosyl-L-methionine (SAMe)]] and [[Guanidinoacetate (GAA)|guanidinoacetate (GAA)]], influence brain phosphagen levels, depression markers, or the effectiveness of antidepressant medications. For instance, SAMe has been found to be a viable treatment for clinical depression. In one study, SAMe supplementation led to increased brain creatine and phosphocreatine (PCr) levels, with a more pronounced effect in women compared to men. {{#pmid:33572884|pmid33572884}} | ||