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Creatine: Difference between revisions
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Robust evidence highlights the significance of creatine on cognitive function, particularly observed in individuals with creatine deficient syndromes known to deplete brain creatine stores. Creatine deficiency syndrome is marked by mental and developmental disorders, including learning delays and seizures. Notably, these symptoms are, to some extent, reversed by creatine supplementation. Human studies have yielded mixed results. While some studies have discovered benefits on cognitive functioning, others found no such effects, as comprehensively reviewed by Roschel and colleagues in 2022. {{#pmid:35267907|pmid35267907}} | Robust evidence highlights the significance of creatine on cognitive function, particularly observed in individuals with creatine deficient syndromes known to deplete brain creatine stores. Creatine deficiency syndrome is marked by mental and developmental disorders, including learning delays and seizures. Notably, these symptoms are, to some extent, reversed by creatine supplementation. Human studies have yielded mixed results. While some studies have discovered benefits on cognitive functioning, others found no such effects, as comprehensively reviewed by Roschel and colleagues in 2022. {{#pmid:35267907|pmid35267907}} | ||
===Potential Anticancer Effects=== | |||
Creatine supplementation is being explored for potential anticancer properties, stemming from its crucial role in energy maintenance within cells, especially concerning the energy shuttle system involving creatine kinase. Research has shown that certain malignant cells and immune cells combating cancer often have low creatine content, which may impact energy availability crucial for their functions. The expression of the creatine transport gene, SLC6A8, notably increases in tumor-infiltrating immune cells, indicating a possible role of creatine in cancer immunity. {{#pmid:33572884|pmid33572884}} | |||
Studies have demonstrated anticancer properties of creatine and its related compound, cyclocreatine. For instance, creatine, when used alongside anticancer medication like methylglyoxal (MG) and ascorbic acid, has shown to significantly enhance the medication's efficacy, even eliminating visible signs of tumor growth in some cases. Creatine supplementation elevated the low creatine and creatine kinase levels in sarcoma tissues, leading to a regression of tumor cells. Further, creatine's administration, either directly or through dietary supplementation, notably suppressed tumor growth in various mouse tumor models, by possibly enhancing the responses of CD8 T cells, which are crucial for tumor immunity. The findings suggest that creatine supplementation could serve as a supportive anticancer therapeutic intervention, especially in enhancing T cell-based cancer immunotherapies, although more research is needed to confirm these effects and understand the underlying mechanisms. {{#pmid:33572884|pmid33572884}} | |||
===Chronic Fatigue Syndrome=== | ===Chronic Fatigue Syndrome=== | ||
Chronic fatigue syndrome (CFS), also known as post-viral fatigue syndrome (PFS) or myalgic encephalomyelitis (ME), is associated with persistent fatigue and other symptoms like muscle pains and cognitive disorders. The exact cause of these conditions is unknown, but recent studies have shown interest in creatine's potential to enhance functional capacity in affected individuals. Some evidence suggests that impaired creatine metabolism may play a role in CFS-related diseases. {{#pmid:33572884|pmid33572884}} | Chronic fatigue syndrome (CFS), also known as post-viral fatigue syndrome (PFS) or myalgic encephalomyelitis (ME), is associated with persistent fatigue and other symptoms like muscle pains and cognitive disorders. The exact cause of these conditions is unknown, but recent studies have shown interest in creatine's potential to enhance functional capacity in affected individuals. Some evidence suggests that impaired creatine metabolism may play a role in CFS-related diseases. {{#pmid:33572884|pmid33572884}} | ||