2,851
edits
Creatine: Difference between revisions
→Potential Anticancer Effects
| Line 61: | Line 61: | ||
Robust evidence highlights the significance of creatine on cognitive function, particularly observed in individuals with creatine deficient syndromes known to deplete brain creatine stores. Creatine deficiency syndrome is marked by mental and developmental disorders, including learning delays and seizures. Notably, these symptoms are, to some extent, reversed by creatine supplementation. Human studies have yielded mixed results. While some studies have discovered benefits on cognitive functioning, others found no such effects, as comprehensively reviewed by Roschel and colleagues in 2022. {{#pmid:35267907|pmid35267907}} | Robust evidence highlights the significance of creatine on cognitive function, particularly observed in individuals with creatine deficient syndromes known to deplete brain creatine stores. Creatine deficiency syndrome is marked by mental and developmental disorders, including learning delays and seizures. Notably, these symptoms are, to some extent, reversed by creatine supplementation. Human studies have yielded mixed results. While some studies have discovered benefits on cognitive functioning, others found no such effects, as comprehensively reviewed by Roschel and colleagues in 2022. {{#pmid:35267907|pmid35267907}} | ||
=== | ===Anticancer Effects=== | ||
Creatine supplementation is being explored for potential anticancer properties, stemming from its crucial role in energy maintenance within cells, especially concerning the energy shuttle system involving creatine kinase. Research has shown that certain malignant cells and immune cells combating cancer often have low creatine content, which may impact energy availability crucial for their functions. The expression of the creatine transport gene, SLC6A8, notably increases in tumor-infiltrating immune cells, indicating a possible role of creatine in cancer immunity. {{#pmid:33572884|pmid33572884}} | Creatine supplementation is being explored for potential anticancer properties, stemming from its crucial role in energy maintenance within cells, especially concerning the energy shuttle system involving creatine kinase. Research has shown that certain malignant cells and immune cells combating cancer often have low creatine content, which may impact energy availability crucial for their functions. The expression of the creatine transport gene, SLC6A8, notably increases in tumor-infiltrating immune cells, indicating a possible role of creatine in cancer immunity. {{#pmid:33572884|pmid33572884}} | ||