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Dose Conversion Between Animals and Human by Allometric Scaling: Difference between revisions
Dose Conversion Between Animals and Human by Allometric Scaling (view source)
Revision as of 12:13, 11 September 2023
, 11 September 2023→Human Equivalent Dose Calculation based on Body Surface Area
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<math>Dose = HED * Weight_{human} = \frac{AED}{K_m\:ratio} * Weight_{human}</math> | <math>Dose = HED * Weight_{human} = \frac{AED}{K_m\:ratio} * Weight_{human}</math> | ||
For example, in <ref>https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5668137/</ref> an NMN admission to mice with 100 mg/kg and 300 mg/kg per day was analyzed. That is equivalent to dose of a 80 kg human of | For example, in <ref>https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5668137/</ref> an [[NMN]] admission to mice with 100 mg/kg and 300 mg/kg per day was analyzed. That is equivalent to dose of a 80 kg human of | ||
<math>Dose1 = \frac{AED}{K_m\:ratio} * Weight_{human} = \frac{100 mg/kg}{12.3} * 80 kg = ~650 mg</math> | <math>Dose1 = \frac{AED}{K_m\:ratio} * Weight_{human} = \frac{100 mg/kg}{12.3} * 80 kg = ~650 mg</math> | ||