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Creatine: Difference between revisions
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=== Creatine Deficiency Syndrome === | === Creatine Deficiency Syndrome === | ||
Robust evidence highlights the significance of creatine on cognitive function, particularly observed in individuals with creatine deficient syndromes known to deplete brain creatine stores. Creatine deficiency syndrome is marked by mental and developmental disorders, including learning delays and seizures. Notably, these symptoms are, to some extent, reversed by creatine supplementation. Human studies have yielded mixed results. While some studies have discovered benefits on cognitive functioning, others found no such effects, as comprehensively reviewed by Roschel and colleagues in 2022. {{#pmid:35267907|pmid35267907}} | Robust evidence highlights the significance of creatine on cognitive function, particularly observed in individuals with creatine deficient syndromes known to deplete brain creatine stores. Creatine deficiency syndrome is marked by mental and developmental disorders, including learning delays and seizures. Notably, these symptoms are, to some extent, reversed by creatine supplementation. Human studies have yielded mixed results. While some studies have discovered benefits on cognitive functioning, others found no such effects, as comprehensively reviewed by Roschel and colleagues in 2022. {{#pmid:35267907|pmid35267907}} | ||
=== Neurodegenerative Diseases and Muscular Dystrophy === | |||
Creatine supplementation has been explored for its potential therapeutic benefits in various neuromuscular diseases like Huntington's, Parkinson's, and Amyotrophic Lateral Sclerosis (ALS), among others. While some animal studies showed improved exercise tolerance or clinical outcomes, a large clinical trial found no significant benefit in Parkinson's or ALS patients. However, some evidence suggests that creatine might slow brain atrophy in Huntington's patients. In the case of muscular dystrophies, creatine supplementation demonstrated more promise, increasing muscle strength and functional performance. The results hint at creatine's neuroprotective properties and its potential to enhance muscle strength and endurance, although the long-term efficacy in neurodegenerative diseases remains unclear. {{#pmid:33572884|pmid33572884}} | |||
===Anticancer Effects=== | ===Anticancer Effects=== | ||