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Creatine: Difference between revisions
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===Brain and Spinal Cord Neuroprotection=== | ===Brain and Spinal Cord Neuroprotection=== | ||
Creatine supplementation is recognized for its ability to enhance brain bioenergetics and provide neuroprotective benefits, especially during injury or ischemic events. Research has explored its impact on cerebral ischemia, stroke, traumatic brain injury (TBI), and spinal cord injury (SCI). For instance, studies in animals have shown that creatine supplementation can significantly reduce brain damage induced by ischemia and may also lessen the severity of TBI and SCI, leading to improved recovery outcomes. In humans, some findings suggest that creatine supplementation could enhance training adaptations in patients recovering from SCI and might aid in improving aerobic exercise capacity and muscle strength. While some human studies didn't report benefits, the compelling evidence from animal models led to recommendations for athletes at risk of TBI or SCI to consider creatine supplementation for potential neuroprotection. {{#pmid:33572884|pmid33572884}} | Creatine supplementation is recognized for its ability to enhance brain bioenergetics and provide neuroprotective benefits, especially during injury or ischemic events. Research has explored its impact on cerebral ischemia, stroke, traumatic brain injury (TBI), and spinal cord injury (SCI). For instance, studies in animals have shown that creatine supplementation can significantly reduce brain damage induced by ischemia and may also lessen the severity of TBI and SCI, leading to improved recovery outcomes. In humans, some findings suggest that creatine supplementation could enhance training adaptations in patients recovering from SCI and might aid in improving aerobic exercise capacity and muscle strength. While some human studies didn't report benefits, the compelling evidence from animal models led to recommendations for athletes at risk of TBI or SCI to consider creatine supplementation for potential neuroprotection. {{#pmid:33572884|pmid33572884}} | ||
===Enhanced Rehabilitation Outcomes=== | |||
Creatine supplementation, known for augmenting resistance-training adaptations, has been explored for its potential to improve rehabilitation outcomes post musculoskeletal injury. Research suggests that creatine supplementation might enhance muscle fiber area and peak strength during rehabilitation, and potentially improve aerobic capacity in patients with spinal cord injuries. Moreover, studies have found positive outcomes in patients with chronic heart failure, chronic obstructive pulmonary disease, Parkinson's disease, and knee osteoarthritis, showing improved muscle strength, endurance, physical function, and quality of life. Creatine supplementation might also expedite recovery post muscle-damaging exercise. However, not all studies share these positive findings; some showed no significant improvement in recovery post orthopedic surgeries like total knee arthroplasty or anterior cruciate ligament reconstruction. While the evidence points towards creatine's potential in enhancing rehabilitation outcomes, more research is needed to better understand its impact across different populations and conditions. {{#pmid:33572884|pmid33572884}} | |||
===Anticancer Effects=== | ===Anticancer Effects=== | ||