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Creatine: Difference between revisions
→Glucose Management and Diabetes
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Creatine supplementation has been associated with influencing glucose management, especially in the context of exercise and dietary practices. The uptake of creatine into tissues is influenced by glucose and insulin levels. Moreover, creatine supplementation has shown potential in preventing declines in the GLUT-4 transporter, which is essential for glucose uptake into cells, during immobilization and even increasing GLUT-4 by 40% during rehabilitation after muscle atrophy. The co-ingestion of creatine with carbohydrates or a combination of carbohydrates and protein has been reported to increase creatine uptake and/or muscle glycogen levels, which could be beneficial for glycogen storage and overall glucose management. {{#pmid:33572884|pmid33572884}} | Creatine supplementation has been associated with influencing glucose management, especially in the context of exercise and dietary practices. The uptake of creatine into tissues is influenced by glucose and insulin levels. Moreover, creatine supplementation has shown potential in preventing declines in the GLUT-4 transporter, which is essential for glucose uptake into cells, during immobilization and even increasing GLUT-4 by 40% during rehabilitation after muscle atrophy. The co-ingestion of creatine with carbohydrates or a combination of carbohydrates and protein has been reported to increase creatine uptake and/or muscle glycogen levels, which could be beneficial for glycogen storage and overall glucose management. {{#pmid:33572884|pmid33572884}} | ||
In a notable study, Gualano et al. evaluated the effects of creatine supplementation (5 g/day for 12 weeks) during training in participants with type 2 diabetes. The findings indicated that creatine supplementation improved glucose tolerance to a standard meal, increased GLUT-4 translocation, and significantly reduced HbA1c levels, which is a long-term indicator of glucose control. Furthermore, the AMPK-alpha protein content, which is related to cellular energy regulation and possibly glucose uptake, tended to be higher after creatine supplementation. This increase was significantly related to the changes observed in GLUT-4 translocation and HbA1c levels, suggesting that AMPK signaling might play a role in the effects of creatine supplementation on glucose uptake in individuals with type 2 diabetes. {{#pmid: | In a notable study, Gualano et al. evaluated the effects of creatine supplementation (5 g/day for 12 weeks) during training in participants with type 2 diabetes. The findings indicated that creatine supplementation improved glucose tolerance to a standard meal, increased GLUT-4 translocation, and significantly reduced HbA1c levels, which is a long-term indicator of glucose control. {{#pmid:20881878|pmid20881878}} Furthermore, the AMPK-alpha protein content, which is related to cellular energy regulation and possibly glucose uptake, tended to be higher after creatine supplementation. This increase was significantly related to the changes observed in GLUT-4 translocation and HbA1c levels, suggesting that AMPK signaling might play a role in the effects of creatine supplementation on glucose uptake in individuals with type 2 diabetes. {{#pmid:22349765|pmid22349765}} | ||
Overall, the evidence suggests that creatine supplementation can enhance glucose uptake and insulin sensitivity, which may help individuals manage their glucose and HbA1c levels, particularly when engaging in an exercise program. Hence, creatine supplementation might offer a supportive role in healthy glucose management, especially in conjunction with exercise and dietary strategies. | Overall, the evidence suggests that creatine supplementation can enhance glucose uptake and insulin sensitivity, which may help individuals manage their glucose and HbA1c levels, particularly when engaging in an exercise program. Hence, creatine supplementation might offer a supportive role in healthy glucose management, especially in conjunction with exercise and dietary strategies. | ||