2,851
edits
Creatine: Difference between revisions
→Glucose Management and Diabetes
| Line 51: | Line 51: | ||
In a notable study, Gualano et al. evaluated the effects of creatine supplementation (5 g/day for 12 weeks) during training in participants with type 2 diabetes. The findings indicated that creatine supplementation improved glucose tolerance to a standard meal, increased GLUT-4 translocation, and significantly reduced HbA1c levels, which is a long-term indicator of glucose control. {{#pmid:20881878|pmid20881878}} Furthermore, the AMPK-alpha protein content, which is related to cellular energy regulation and possibly glucose uptake, tended to be higher after creatine supplementation. This increase was significantly related to the changes observed in GLUT-4 translocation and HbA1c levels, suggesting that AMPK signaling might play a role in the effects of creatine supplementation on glucose uptake in individuals with type 2 diabetes. {{#pmid:22349765|pmid22349765}} | In a notable study, Gualano et al. evaluated the effects of creatine supplementation (5 g/day for 12 weeks) during training in participants with type 2 diabetes. The findings indicated that creatine supplementation improved glucose tolerance to a standard meal, increased GLUT-4 translocation, and significantly reduced HbA1c levels, which is a long-term indicator of glucose control. {{#pmid:20881878|pmid20881878}} Furthermore, the AMPK-alpha protein content, which is related to cellular energy regulation and possibly glucose uptake, tended to be higher after creatine supplementation. This increase was significantly related to the changes observed in GLUT-4 translocation and HbA1c levels, suggesting that AMPK signaling might play a role in the effects of creatine supplementation on glucose uptake in individuals with type 2 diabetes. {{#pmid:22349765|pmid22349765}} | ||
Overall, the evidence suggests that creatine supplementation can enhance glucose uptake and insulin sensitivity, which may help individuals manage their glucose and HbA1c levels, particularly when engaging in an exercise program. Hence, creatine supplementation might offer a supportive role in healthy glucose management, especially in conjunction with exercise and dietary strategies. | Overall, the evidence suggests that creatine supplementation can enhance glucose uptake and insulin sensitivity, which may help individuals manage their glucose and HbA1c levels, particularly when engaging in an exercise program. Hence, creatine supplementation might offer a supportive role in healthy glucose management, especially in conjunction with exercise and dietary strategies.{{#pmid:33572884|pmid33572884}} | ||
=== Heart Disease === | |||
Coronary artery disease, which restricts blood flow to the heart, increases the risk of ischemic events, arrhythmias, and heart failure. Creatine and its derivative, phosphocreatine (PCr), are known to help maintain heart energy levels during these ischemic events. This has led to interest in exploring creatine or PCr administration as a way to reduce heart-related issues in individuals with chronic heart failure. {{#pmid:33572884|pmid33572884}} | |||
Studies have shown promising results. For example, administering PCr and phosphocreatinine intravenously in canines prevented harmful substance accumulation in the heart's ischemic zone, reducing arrhythmia prevalence. Similarly, other researchers found that exogenous PCr administration protected against heart ischemia. When PCr was added to solutions used to preserve heart tissue during ischemia, it improved energy availability, reduced arrhythmia incidence, and improved heart function. {{#pmid:33572884|pmid33572884}} | |||
Additionally, creatine supplementation has shown potential benefits for heart failure patients engaged in rehabilitation programs, though results vary across studies. While more research is essential, current findings suggest that phosphocreatine administration and possibly creatine supplementation may support heart metabolism and health, especially during ischemic challenges. {{#pmid:33572884|pmid33572884}} | |||
==Potential Health Benefits== | ==Potential Health Benefits== | ||