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Creatine: Difference between revisions
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The average daily food intake for an adult female C57BL/6 mouse is approximately 2.5 to 5 grams per day and the typical weight is 20-25 grams. 1% of 3.75 g is 0.035 g creatine per day. 0.035 g / 22.5 is ~1555 mg/kg dose. That converts to ~126 mg/kg human equivalent dose or ~9500 mg/day for a 75 kg person. | The average daily food intake for an adult female C57BL/6 mouse is approximately 2.5 to 5 grams per day and the typical weight is 20-25 grams. 1% of 3.75 g is 0.035 g creatine per day. 0.035 g / 22.5 is ~1555 mg/kg dose. That converts to ~126 mg/kg human equivalent dose or ~9500 mg/day for a 75 kg person. | ||
The average daily food intake for an adult female C57BL/6 mouse ranges from approximately 2.5 to 5 grams, with a typical weight of 20-25 grams. If we take the average food intake to be 3.75 grams, then a 1% inclusion of creatine in this diet corresponds to a creatine intake of 0.035 grams per day. To calculate the creatine dose in mg/kg, divide the creatine intake by the average weight of the mouse (assuming 22.5 grams), resulting in a dose of approximately 1555 mg/kg. Converting this mouse dose to a human equivalent dose (HED) using a conversion factor | The average daily food intake for an adult female C57BL/6 mouse ranges from approximately 2.5 to 5 grams, with a typical weight of 20-25 grams. If we take the average food intake to be 3.75 grams, then a 1% inclusion of creatine in this diet corresponds to a creatine intake of 0.035 grams per day. To calculate the creatine dose in mg/kg, divide the creatine intake by the average weight of the mouse (assuming 22.5 grams), resulting in a dose of approximately 1555 mg/kg. Converting this mouse dose to a human equivalent dose (HED) using [[Allometric Scaling|allometric scaling]] with a conversion factor of 12.3, the HED is around 126 mg/kg. For a 75 kg human, this dose translates to about 9450 mg/day. | ||
=== Muscle Mass, Strength, Bone and Body Composition === | === Muscle Mass, Strength, Bone and Body Composition === | ||