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Creatine: Difference between revisions

735 bytes added ,  29 October 2023
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===Lifespan===
===Lifespan===
[[File:Creatine mice lifespan.gif|thumb|Survival rate of wild type mice after starting 1% creatine submission beginning in the age of 365 days]]
[[File:Creatine mice lifespan.gif|thumb|Survival rate of wild type mice after starting 1% creatine submission beginning in the age of 365 days]]
In animal studies, creatine supplementation has been associated with a 9% increase in lifespan. Creatine-fed mice also demonstrated significantly better performance on neurobehavioral testing. While human trials are needed to confirm these findings, they suggest a potential benefit of creatine supplementation for longevity.
In animal studies, creatine supplementation has been associated with a 9% increase in lifespan. Creatine-fed mice also demonstrated significantly better performance on neurobehavioral testing. While human trials are needed to confirm these findings, they suggest a potential benefit of creatine supplementation for longevity. {{#pmid:17416441|pmid17416441}}
 


The average daily food intake for an adult female C57BL/6 mouse is approximately 2.5 to 5 grams per day and the typical weight is 20-25 grams. 1% of 3.75 g is 0.035 g creatine per day. 0.035 g / 22.5 is ~1555 mg/kg dose. That converts to ~126 mg/kg human equivalent dose or ~9500 mg/day for a 75 kg person.
The average daily food intake for an adult female C57BL/6 mouse is approximately 2.5 to 5 grams per day and the typical weight is 20-25 grams. 1% of 3.75 g is 0.035 g creatine per day. 0.035 g / 22.5 is ~1555 mg/kg dose. That converts to ~126 mg/kg human equivalent dose or ~9500 mg/day for a 75 kg person.


{{#pmid:17416441|pmid17416441}}
The average daily food intake for an adult female C57BL/6 mouse ranges from approximately 2.5 to 5 grams, with a typical weight of 20-25 grams. If we take the average food intake to be 3.75 grams, then a 1% inclusion of creatine in this diet corresponds to a creatine intake of 0.035 grams per day. To calculate the creatine dose in mg/kg, divide the creatine intake by the average weight of the mouse (assuming 22.5 grams), resulting in a dose of approximately 1555 mg/kg. Converting this mouse dose to a human equivalent dose (HED) using a conversion factor (K_m factor) of 12.3 (mouse K_m factor of 3 divided by human K_m factor of 0.244), the HED is around 126 mg/kg. For a 75 kg human, this dose translates to about 9450 mg/day.


=== Muscle Mass, Strength, Bone and Body Composition ===
=== Muscle Mass, Strength, Bone and Body Composition ===
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