Resveratrol: Difference between revisions

Resveratrol has garnered significant attention in the scientific community for its potential role in promoting health and longevity. This section delves into the intricate relationship between resveratrol and aging, exploring its effects on lifespan and age-related diseases. <ref>https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8289612/</ref>

[[File:Resveratrol Improves Health and Survival of Mice on a High-calorie Diet.png|thumb|[[Kaplan–Meier Survival Curve|Kaplan–Meier survival curves]] of mice fed a standard diet, high-calorie diet or high-calorie diet plus resveratrol <ref name=":3" />]]

In <ref name=":3">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4990206/</ref> mice fed a standard diet, high-calorie diet or high-calorie diet plus resveratrol. The study found that resveratrol helps mice on a high-calorie diet have similar health benefits to mice on a regular diet. This includes better lifespan, movement, insulin response, organ health, and improved mitochondrial function. Importantly, these benefits happened without the mice losing weight.

A recent study <ref>https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10346321/</ref> in a [[Randomized Controlled Trial|randomized trial]] involving adults aged 55 to 65 compared the effects of resveratrol supplementation to a caloric-restricted diet. Both interventions raised circulating SIRT1 levels and reduced plasma noradrenaline, suggesting cardiovascular benefits. However, the study found differences between the groups in vascular reactions. Specifically, improvements in [[Nitrate-Mediated Vasodilation (NMD)|nitrate-mediated vasodilation (NMD)]] were seen only with caloric restriction, not with resveratrol. Additionally, SIRT1 was linked to enhanced flow-mediated vasodilation (FMD) in men but not in women. This suggests that while resveratrol mirrors some benefits of caloric restriction, it doesn't capture all, especially regarding vascular effects.

In 2021 [[Randomized Controlled Trial]], participants receive a single dose of resveratrol 2500 mg, with piperine in 0 mg, 5 mg or 25 mg dose. Despite the observation of piperine coadministration significantly increasing bioavailability ([[Cmax|C_max]] and [[AUC|AUC)]] of resveratrol in [[C57BL/6 mice|C57BL]] mice, no significant increase in resveratrol or decrease in resveratrol glucuronide could be observed in healthy adults taking 2500 gm of resveratrol with piperine (5 or 25 mg) as compared to resveratrol alone. <ref>https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7910313/</ref>

The recommended dosage for adults is generally between 150 to 500 mg per day, although this can vary based on individual health conditions and specific product formulations. In a study <ref name=":1">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2982884/</ref>, participants received resveratrol for 29 days at doses of up to 5.0g per day.  

Resveratrol should not be taken with high-fat meals. In a study <ref name=":2">https://pubmed.ncbi.nlm.nih.gov/20528005/</ref>, a high-fat breakfast significantly decreased the bioavailability by 45% when compared with a standard breakfast.

Combined intake with quercetin or alcohol does not influence trans-resveratrol exposure. <ref name=":2" />

Some people may experience gastrointestinal issues, headaches, or a feeling of jitteriness. In the mentioned study <ref name=":1" />, the majority of adverse events in the higher doses (2.5g and 5.0g) were gastrointestinal symptoms, including nausea, flatulence, abdominal discomfort, and diarrhea. Symptoms typically began 2-4 days into the regimen and improved as the day progressed but would return after the next dose. They resolved within 2 days of completing the 29-day regimen.