Procyanidin C1 (PCC1): Difference between revisions

Procyanidin C1 (PCC1) (view source)

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-'''Procyanidin C1''' (PCC1) is a molecule found in grape (''[[wikipedia:Vitis_vinifera|Vitis vinifera]]''),<ref>Proanthocyanidin composition of red Vitis vinifera varieties from the Douro valley during ripening : Influence of cultivation altitude. Mateus Nuno, Marques Sara, Goncalves Ana C., Machado José M. and De Freitas Victor, American journal of enology and viticulture, 2001, vol. 52, no2, pp. 115-121, {{INIST|1129642}}</ref> unripe apples,<ref name="Nakano Nishiyama Tokura Nagasako-Akazome 2008 pp. 213–2212">{{cite journal|last1=Nakano|title=Procyanidin C1 from Apple Extracts Inhibits FcεRI-Mediated Mast Cell Activation|url=https://www.karger.com/Article/FullText/142044|s2cid=43866026|pages=213–221|doi=10.1159/000142044|pmid=18594151|issn=1018-2438|date=2008-07-02|issue=3|volume=147|journal=International Archives of Allergy and Immunology|first7=Hideoki|first1=Nobuhiro|last7=Ogawa|first6=Ko|last6=Okumura|first5=Yasuyuki|last5=Ohtake|first4=Yoko|last4=Nagasako-Akazome|first3=Tomoko|last3=Tokura|first2=Chiharu|last2=Nishiyama|access-date=2022-02-20}}</ref> and [[wikipedia:Cinnamon|cinnamon]].<ref name="Sun Li Wang Ji pp. 8839–88462">{{cite journal|last1=Sun|first8=Yi-Ming|pmid=31334651|pages=8839–8846|doi=10.1021/acs.jafc.9b02932|issn=0021-8561|date=2019-07-23|issue=32|volume=67|publisher=American Chemical Society (ACS)|journal=Journal of Agricultural and Food Chemistry|title=Procyanidin C1, a Component of Cinnamon Extracts, Is a Potential Insulin Sensitizer That Targets Adipocytes|first9=He-Yao|last9=Wang|last8=Li|first1=Peng|first7=Qi|last7=Jia|first6=Kai-Xian|last6=Chen|first5=Yan|last5=Wang|first4=Jun|last4=Ji|first3=Ting|last3=Wang|first2=Kai|last2=Li|s2cid=198169719}}</ref> It can be isolated from grape seed extract
+'''Procyanidin C1''' (PCC1) is a molecule found in grape (''[[wikipedia:Vitis_vinifera|Vitis vinifera]]''),<ref>Proanthocyanidin composition of red Vitis vinifera varieties from the Douro valley during ripening : Influence of cultivation altitude. Mateus Nuno, Marques Sara, Goncalves Ana C., Machado José M. and De Freitas Victor, American journal of enology and viticulture, 2001, vol. 52, no2, pp. 115-121, {{INIST|1129642}}</ref> unripe apples,{{#pmid:18594151|pmid18594151}} and [[wikipedia:Cinnamon|cinnamon]].{{#pmid:31334651|pmid31334651}} It can be isolated from grape seed extract
 <ref name="Wong">{{cite journal|last1=Carissa Wong|title=Grape seed chemical allows mice to live longer by killing aged cells|journal=New Scientist|date=Dec 6, 2021|url=https://www.newscientist.com/article/2300346-grape-seed-chemical-allows-mice-to-live-longer-by-killing-aged-cells/}}</ref> and is [[wikipedia:Phenolic_content_in_wine|content in wine]].
-Procyanidin C1 has been shown to be an effective [[wikipedia:Senolytic|senolytic]] agent in wild-type mice, with effects of increased lifespan (+9.4%), reduced senescence markers and making them fitter. It was also found to greatly increase the effectiveness of [[wikipedia:Chemotherapy|chemotherapy]] in mice in which human [[wikipedia:Prostate_cancer|prostate tumor cells]] were implanted.<ref name="Wong3">{{cite journal|last1=Carissa Wong|title=Grape seed chemical allows mice to live longer by killing aged cells|journal=New Scientist|date=Dec 6, 2021|url=https://www.newscientist.com/article/2300346-grape-seed-chemical-allows-mice-to-live-longer-by-killing-aged-cells/}}</ref><ref>{{cite journal|last1=Xu|first1=Qixia|title=The flavonoid procyanidin C1 has senotherapeutic activity and increases lifespan in mice|journal=Nature Metabolism|date=Dec 6, 2021|volume=3|issue=12|pages=1706–1726|display-authors=etal|doi=10.1038/s42255-021-00491-8|pmid=34873338|pmc=8688144}}</ref>
+Procyanidin C1 has been shown to be an effective [[wikipedia:Senolytic|senolytic]] agent in wild-type mice, with effects of increased lifespan (+9.4%), reduced senescence markers and making them fitter. It was also found to greatly increase the effectiveness of [[wikipedia:Chemotherapy|chemotherapy]] in mice in which human [[wikipedia:Prostate_cancer|prostate tumor cells]] were implanted.{{#pmid:34873338|pmid34873338}}
 == Studies ==