Procyanidin C1 (PCC1): Difference between revisions

Procyanidin C1 (PCC1) (view source)

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-'''Procyanidin C1''' (PCC1) is a molecule found in grape (''[[wikipedia:Vitis_vinifera|Vitis vinifera]]''),<ref>Proanthocyanidin composition of red Vitis vinifera varieties from the Douro valley during ripening : Influence of cultivation altitude. Mateus Nuno, Marques Sara, Goncalves Ana C., Machado José M. and De Freitas Victor, American journal of enology and viticulture, 2001, vol. 52, no2, pp. 115-121, {{INIST|1129642}}</ref> unripe apples,{{#pmid:18594151|pmid18594151}} and [[wikipedia:Cinnamon|cinnamon]].{{#pmid:31334651|pmid31334651}} It can be isolated from grape seed extract
+'''Procyanidin C1''' (PCC1) is a molecule found in grape (''[[wikipedia:Vitis_vinifera|Vitis vinifera]]''),<ref>Proanthocyanidin composition of red Vitis vinifera varieties from the Douro valley during ripening : Influence of cultivation altitude. Mateus Nuno, Marques Sara, Goncalves Ana C., Machado José M. and De Freitas Victor, American journal of enology and viticulture, 2001, vol. 52, no2, pp. 115-121, {{INIST|1129642}}</ref> unripe apples,{{#pmid:18594151|pmid18594151}} and [[wikipedia:Cinnamon|cinnamon]].{{#pmid:31334651|pmid31334651}} It can be isolated from grape seed extract and is [[wikipedia:Phenolic_content_in_wine|content in wine]].
-<ref name="Wong">{{cite journal|last1=Carissa Wong|title=Grape seed chemical allows mice to live longer by killing aged cells|journal=New Scientist|date=Dec 6, 2021|url=https://www.newscientist.com/article/2300346-grape-seed-chemical-allows-mice-to-live-longer-by-killing-aged-cells/}}</ref> and is [[wikipedia:Phenolic_content_in_wine|content in wine]].
 Procyanidin C1 has been shown to be an effective [[wikipedia:Senolytic|senolytic]] agent in wild-type mice, with effects of increased lifespan (+9.4%), reduced senescence markers and making them fitter. It was also found to greatly increase the effectiveness of [[wikipedia:Chemotherapy|chemotherapy]] in mice in which human [[wikipedia:Prostate_cancer|prostate tumor cells]] were implanted.{{#pmid:34873338|pmid34873338}}