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Caloric Restriction: Difference between revisions
→Increased Formation of Ketone Bodies
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Ketone bodies protect neurons against various types of neuronal injuries. This is one explanation for the beneficial effect of caloric restriction in the animal model of neurological diseases.{{pmid|25896951}} | Ketone bodies protect neurons against various types of neuronal injuries. This is one explanation for the beneficial effect of caloric restriction in the animal model of neurological diseases.{{pmid|25896951}} | ||
=== Increased Autophagy === | |||
[[Autophagy]], also known as “cellular self-digestion”, is a cellular pathway involved in the breakdown of [[Protein|proteins]] and [[Organelle|organelles]], and plays a role in various diseases. Dysfunctions in autophagy are associated with [[Neurodegeneration|neurodegenerative diseases]], microbial [[Infection|infections]], and [[Aging|aging]]. | |||
Several indications suggest that autophagy is important for the effects of calorie restriction: The efficiency of autophagy decreases with age; the decline in autophagy is associated with changes in aging biomarkers; the age-dependent change in autophagy is prevented experimentally by calorie restriction; preventing a decrease in autophagy efficiency mimics the effects of calorie restriction; prolonged inhibition of autophagy accelerates the aging process; conversely, prolonged stimulation of autophagy delays the aging process in [[Rat|rats]]; stimulating autophagy can protect older cells from accumulation of altered [[Mitochondrial DNA|mitochondrial DNA]]; stimulating autophagy alleviates age-related hypercholesterolemia in rodents.{{pmid|23331488}} | |||
A comparable effect was observed in plants whose lighting was reduced.{{pmid|20021367}} | |||
==Benefits of Caloric Restriction== | ==Benefits of Caloric Restriction== | ||
Research suggests that caloric restriction may offer several health benefits, including: | Research suggests that caloric restriction may offer several health benefits, including: | ||