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Caloric Restriction: Difference between revisions
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=== "Reprogramming" of Metabolism and Gene Expression === | === "Reprogramming" of Metabolism and Gene Expression === | ||
According to another theory, long-term reduced food intake "reprograms" the metabolism.{{pmid|17063031}} In mice under caloric restriction, a changed [[Gene expression|gene expression]] has been observed. On one hand, genes involved in [[Metabolism|energy metabolism]] are overexpressed,{{pmid|14688200}} while on the other hand, over 50 [[Inflammation|pro-inflammatory]] genes are downregulated.{{pmid|16424110}}{{pmid|19075044}} It's possible that the regeneration of some [[Stem cell|stem cells]] is enhanced.{{pmid|24211426}} In some strains of mice, a similar effect can be induced by [[Metformin]].{{pmid|25269675}} | According to another theory, long-term reduced food intake "reprograms" the metabolism.{{pmid|17063031}} In mice under caloric restriction, a changed [[Gene expression|gene expression]] has been observed. On one hand, genes involved in [[Metabolism|energy metabolism]] are overexpressed,{{pmid|14688200}} while on the other hand, over 50 [[Inflammation|pro-inflammatory]] genes are downregulated.{{pmid|16424110}}{{pmid|19075044}} It's possible that the regeneration of some [[Stem cell|stem cells]] is enhanced.{{pmid|24211426}} In some strains of mice, a similar effect can be induced by [[Metformin]].{{pmid|25269675}} | ||
===Increased Formation of Ketone Bodies=== | |||
Both caloric restriction and the [[ketogenic diet]] have therapeutic potential in various animal models of neurological diseases.{{pmid|18845187}} Under caloric restriction, there is a [[Ketone body#Ketogenesis|transition from glucose metabolism to the use of ketone bodies]]. Ketone bodies can be used as an alternative energy source for brain cells when glucose availability is poor.{{pmid|25896951}} | |||
Ketone bodies protect neurons against various types of neuronal injuries. This is one explanation for the beneficial effect of caloric restriction in the animal model of neurological diseases.{{pmid|25896951}} | |||
==Benefits of Caloric Restriction== | ==Benefits of Caloric Restriction== | ||
Research suggests that caloric restriction may offer several health benefits, including: | Research suggests that caloric restriction may offer several health benefits, including: | ||