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Caloric Restriction: Difference between revisions
→Risks of Calorie Restriction in Humans
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Long-term [[Malnutrition|undernutrition]] can, besides positive effects, also lead to various [[Deficiency disease|deficiency diseases]]. Developmental disorders can occur in minors. Cold sensitivity may increase.{{pmid|19944269}} Ovulation can be suspended in women with very low BMI, resulting in temporary infertility. | Long-term [[Malnutrition|undernutrition]] can, besides positive effects, also lead to various [[Deficiency disease|deficiency diseases]]. Developmental disorders can occur in minors. Cold sensitivity may increase.{{pmid|19944269}} Ovulation can be suspended in women with very low BMI, resulting in temporary infertility. | ||
{{pmid|19944269}} In the [[Minnesota Starvation Experiment]], anemia, edema in the lower extremities, muscle wasting, weakness, neurological impairments, dizziness, irritability, lethargy, and depression were observed in adult males undergoing a six-month calorie restriction with a 90% carbohydrate diet.{{cite book|last1=Keys|first1=A.|last2=Brozek|first2=J.|last3=Henschels|first3=A.|last4=Mickelsen|first4=O.|last5=Taylor|first5=H.|title=The Biology of Human Starvation|year=1950|volume=2|publisher=University of Minnesota Press|location=Minneapolis|page=1133}} | {{pmid|19944269}} In the [[Minnesota Starvation Experiment]], anemia, edema in the lower extremities, muscle wasting, weakness, neurological impairments, dizziness, irritability, lethargy, and depression were observed in adult males undergoing a six-month calorie restriction with a 90% carbohydrate diet.<ref>{{cite book|last1=Keys|first1=A.|last2=Brozek|first2=J.|last3=Henschels|first3=A.|last4=Mickelsen|first4=O.|last5=Taylor|first5=H.|title=The Biology of Human Starvation|year=1950|volume=2|publisher=University of Minnesota Press|location=Minneapolis|page=1133}}</ref> Short-term calorie restriction can lead to muscle wasting and reduced [[Bone density|bone density]].{{pmid|19851100}} In individuals with low body fat, calorie restriction can be harmful.{{pmid|17341713}} | ||
Short-term calorie restriction can lead to muscle wasting and reduced [[Bone density|bone density]].{{pmid|19851100}} | |||
In individuals with low body fat, calorie restriction can be harmful.{{pmid|17341713}} | |||
== Mechanism == | == Mechanism == | ||