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Nicotinamide Mononucleotide (NMN): Difference between revisions
Nicotinamide Mononucleotide (NMN) (view source)
Revision as of 00:03, 20 December 2023
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The relationship between curcumin and sirtuins, particularly in the context of NAD+ boosting, is a promising area of research. However, the effectiveness of combining curcumin with NAD+ enhancing supplements needs to be explored further in clinical trials. Such studies would help establish whether curcumin can augment the benefits of NAD+ precursors, potentially leading to more effective anti-aging therapies. | The relationship between curcumin and sirtuins, particularly in the context of NAD+ boosting, is a promising area of research. However, the effectiveness of combining curcumin with NAD+ enhancing supplements needs to be explored further in clinical trials. Such studies would help establish whether curcumin can augment the benefits of NAD+ precursors, potentially leading to more effective anti-aging therapies. | ||
===Alpha-Ketoglutarate=== | |||
Alpha-ketoglutarate (aKG) is a critical metabolic intermediate in the Krebs cycle, playing an important role in the aging process{{pmid|32877686}}. Its involvement in various longevity-related mechanisms makes it a significant compound in geroprotection and anti-aging research. | |||
*'''Inhibition of the TOR Pathway''': aKG is known to inhibit the TOR pathway, akin to the effects of caloric restriction. This inhibition, coupled with its ability to hinder ATP synthase, has been shown to extend the lifespan in ''C. elegans''{{pmid|24828042}}. | |||
*'''Metabolic and Antioxidant Benefits''': Providing both metabolic and antioxidant benefits, aKG has been demonstrated to extend lifespan. This effect is evident not only in model organisms but also in mice. Recent pilot clinical trials have indicated that Rejuvant, a novel formulation of aKG, effectively reduces biological age in humans{{pmid|33340716}}{{pmid|34847066}}{{pmid|32877690}}. | |||
*'''Interplay with NAD+''': The relationship between aKG and NAD+, a vital coenzyme for cellular health and aging, remains under-researched. Future studies should explore this interaction to enhance our understanding of how aKG can be utilized in longevity therapies. | |||
The potential of aKG in anti-aging strategies is promising, but more research is necessary to fully understand its interactions, particularly with NAD+. | |||
==Clinical Trials== | ==Clinical Trials== | ||
Starting in 2020, with the assessment of the safety of a single dose administration of NMN, there have been around 10 randomized controlled trials (RCTs) exploring the compound's effects in various contexts. The trials have varied in duration, with the longest running for 12 weeks. In terms of dosage, they have explored a range of quantities, with the highest being 1,250 mg of NMN per day and 2,000 mg (2 g) of MIB-626, a specific formulation of NMN, per day. The following table provides a comprehensive overview of these trials, detailing their design, participant demographics, dosages, and key findings: | Starting in 2020, with the assessment of the safety of a single dose administration of NMN, there have been around 10 randomized controlled trials (RCTs) exploring the compound's effects in various contexts. The trials have varied in duration, with the longest running for 12 weeks. In terms of dosage, they have explored a range of quantities, with the highest being 1,250 mg of NMN per day and 2,000 mg (2 g) of MIB-626, a specific formulation of NMN, per day. The following table provides a comprehensive overview of these trials, detailing their design, participant demographics, dosages, and key findings: | ||