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Nicotinamide Mononucleotide (NMN): Difference between revisions
Nicotinamide Mononucleotide (NMN) (view source)
Revision as of 23:58, 19 December 2023
, 19 December 2023→Synergistic Supplements in Conjunction with NMN
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In summary, resveratrol and pterostilbene, especially when used in combination with NMN, represent a strategic orthomolecular approach to enhancing longevity and managing age-related diseases. | In summary, resveratrol and pterostilbene, especially when used in combination with NMN, represent a strategic orthomolecular approach to enhancing longevity and managing age-related diseases. | ||
=== | === CoQ10 === | ||
[[Coenzyme Q10 (CoQ10)]], also known as ubiquinol in its oxidized form, ubiquinone, is a crucial component in the mitochondrial electron transport chain. Its role in cellular energy production and as an antioxidant makes it integral to health, particularly in the context of neurodegenerative disorders, diabetes, cancer, fibrosis, and cardiovascular diseases{{pmid|25126052}}. CoQ10 supplementation, especially in disease states, is aimed at restoring antioxidant activity to correct homeostatic imbalances{{pmid|24389208}}. | [[Coenzyme Q10 (CoQ10)]], also known as ubiquinol in its oxidized form, ubiquinone, is a crucial component in the mitochondrial electron transport chain. Its role in cellular energy production and as an antioxidant makes it integral to health, particularly in the context of neurodegenerative disorders, diabetes, cancer, fibrosis, and cardiovascular diseases{{pmid|25126052}}. CoQ10 supplementation, especially in disease states, is aimed at restoring antioxidant activity to correct homeostatic imbalances{{pmid|24389208}}. | ||
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Both astaxanthin and lycopene exhibit promising roles in geroprotective strategies, particularly in enhancing NAD+ levels and SIRT1 activation. Their combined use with NMN or other NAD+ precursors could potentially maximize the efficacy of interventions aimed at boosting NAD+ availability and combating age-related decline. | Both astaxanthin and lycopene exhibit promising roles in geroprotective strategies, particularly in enhancing NAD+ levels and SIRT1 activation. Their combined use with NMN or other NAD+ precursors could potentially maximize the efficacy of interventions aimed at boosting NAD+ availability and combating age-related decline. | ||
=== Curcumin === | |||
'''[[Curcumin]]''', a compound derived from turmeric, is gaining recognition as a potent senolytic agent, similar to the flavonoids previously discussed (Figure 2). Its effects on aging and age-related pathologies are significant and multifaceted: | |||
* '''Senescence and Longevity Pathways''': Curcumin has shown promising results in improving cellular senescence associated with aging. It also modulates key longevity pathways, such as mTOR and FoxO, indicating its potential in extending healthy lifespan{{pmid|30871021}}. | |||
* '''Neurodegenerative Diseases''': In the realm of neurodegeneration, curcumin has been found to upregulate SIRT1, a protein linked to aging and cellular health{{pmid|30145851}}. This effect suggests its potential in mitigating neurodegenerative disorders. | |||
* '''Cardiovascular Health''': Curcumin's impact on cardiovascular health is highlighted by its ability to activate AMPK, another significant pathway in aging and metabolic regulation{{pmid|30145851}}. | |||
* '''Anti-cancer Properties''': Experimental models of head and neck squamous cell carcinoma have shown that curcumin can inhibit cancer cell migration and angiogenesis, underscoring its anti-cancer potential{{pmid|26299580}}. | |||
* '''Physical Performance''': A six-week supplementation with curcumin in human runners has led to improvements in antioxidant capacity and aerobic performance. This benefit is accompanied by an increase in SIRT3, a mitochondrial protein linked to energy metabolism{{pmid|36125053}}. | |||
The relationship between curcumin and sirtuins, particularly in the context of NAD+ boosting, is a promising area of research. However, the effectiveness of combining curcumin with NAD+ enhancing supplements needs to be explored further in clinical trials. Such studies would help establish whether curcumin can augment the benefits of NAD+ precursors, potentially leading to more effective anti-aging therapies. | |||
==Clinical Trials== | ==Clinical Trials== | ||
Starting in 2020, with the assessment of the safety of a single dose administration of NMN, there have been around 10 randomized controlled trials (RCTs) exploring the compound's effects in various contexts. The trials have varied in duration, with the longest running for 12 weeks. In terms of dosage, they have explored a range of quantities, with the highest being 1,250 mg of NMN per day and 2,000 mg (2 g) of MIB-626, a specific formulation of NMN, per day. The following table provides a comprehensive overview of these trials, detailing their design, participant demographics, dosages, and key findings: | Starting in 2020, with the assessment of the safety of a single dose administration of NMN, there have been around 10 randomized controlled trials (RCTs) exploring the compound's effects in various contexts. The trials have varied in duration, with the longest running for 12 weeks. In terms of dosage, they have explored a range of quantities, with the highest being 1,250 mg of NMN per day and 2,000 mg (2 g) of MIB-626, a specific formulation of NMN, per day. The following table provides a comprehensive overview of these trials, detailing their design, participant demographics, dosages, and key findings: | ||