2,851
edits
SIRT6: Difference between revisions
→Activating Compounds
No edit summary |
|||
| Line 15: | Line 15: | ||
== Modulating Compounds == | == Modulating Compounds == | ||
=== Activating Compounds === | === Activating Compounds === | ||
Activating compounds, also known as agonists, are molecules that can enhance the activity of SIRT6, thereby influencing its role in longevity, metabolism, and DNA repair. These compounds typically bind to SIRT6 and induce a conformational change that increases its enzymatic activity or stability, leading to amplified beneficial effects in cellular processes related to aging and disease prevention. The table below lists several compounds identified through scientific research as activators of SIRT6. Their effectiveness is usually measured in terms of EC<sub>50</sub> values, which indicate the concentration needed to achieve half the maximal activation, and the fold increase in activity they produce. This section provides an overview of some key compounds that have been studied for their potential to enhance the function of SIRT6 and thereby contribute to longevity and healthspan. | Activating compounds, also known as agonists, are molecules that can enhance the activity of SIRT6, thereby influencing its role in longevity, metabolism, and DNA repair. These compounds typically bind to SIRT6 and induce a conformational change that increases its enzymatic activity or stability, leading to amplified beneficial effects in cellular processes related to aging and disease prevention. The table below lists several compounds identified through scientific research as activators of SIRT6. Their effectiveness is usually measured in terms of [[EC50|EC<sub>50</sub>]] values, which indicate the concentration needed to achieve half the maximal activation, and the fold increase in activity they produce. This section provides an overview of some key compounds that have been studied for their potential to enhance the function of SIRT6 and thereby contribute to longevity and healthspan. | ||
{| class="wikitable" | {| class="wikitable" | ||