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SIRT6: Difference between revisions
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===Metabolic Regulation=== | ===Metabolic Regulation=== | ||
SIRT6 also plays a critical role in regulating metabolism, including glucose and lipid metabolism, which are vital for healthy aging. It affects the expression of genes involved in metabolic pathways, influencing longevity and age-associated diseases. | SIRT6 also plays a critical role in regulating metabolism, including glucose and lipid metabolism, which are vital for healthy aging. It affects the expression of genes involved in metabolic pathways, influencing longevity and age-associated diseases. | ||
==Research Findings== | ==Research Findings== | ||
Numerous studies have highlighted the potential of SIRT6 in extending healthspan and lifespan. For example, mice with overexpressed SIRT6 show signs of extended lifespan and improved health markers. Similarly, research in human cells indicates that SIRT6 may protect against age-related decline. | Numerous studies have highlighted the potential of SIRT6 in extending healthspan and lifespan. For example, mice with overexpressed SIRT6 show signs of extended lifespan and improved health markers. Similarly, research in human cells indicates that SIRT6 may protect against age-related decline. | ||
==Potential Implications== | ==Potential Implications== | ||
The study of SIRT6 opens up possibilities for therapeutic interventions in aging and metabolic diseases. Understanding its mechanisms can lead to the development of drugs or therapies aimed at mimicking its longevity effects. | The study of SIRT6 opens up possibilities for therapeutic interventions in aging and metabolic diseases. Understanding its mechanisms can lead to the development of drugs or therapies aimed at mimicking its longevity effects. | ||
== Modulating Compounds == | == Modulating Compounds == | ||
=== Activating Compounds === | |||
Activating compounds, also known as agonists, are molecules that can enhance the activity of SIRT6, thereby influencing its role in longevity, metabolism, and DNA repair. These compounds typically bind to SIRT6 and induce a conformational change that increases its enzymatic activity or stability, leading to amplified beneficial effects in cellular processes related to aging and disease prevention. The table below lists several compounds identified through scientific research as activators of SIRT6. Their effectiveness is usually measured in terms of EC<sub>50</sub> values, which indicate the concentration needed to achieve half the maximal activation, and the fold increase in activity they produce. This section provides an overview of some key compounds that have been studied for their potential to enhance the function of SIRT6 and thereby contribute to longevity and healthspan. | |||
{| class="wikitable" | {| class="wikitable" | ||
! | ! Compound | ||
! | ! [[EC50|EC<sub>50</sub>]] value (µM) | ||
! | ! Maximal activation (fold) | ||
|- | |- | ||
| Luteolin | |||
| 270 ± 25 | |||
| 6.1 | |||
|- | |- | ||
| Kaempferol | |||
| n.d | |||
| 3.0 | |||
|- | |- | ||
| [[Quercetin]] | |||
| 990 ± 250 | |||
| 10 | |||
|- | |- | ||
| Myricetin | |||
| 404 ± 20 | |||
| 7.7 | |||
|- | |- | ||
| Cyanidin | |||
| 460 ± 20 | |||
| 55 | |||
|- | |- | ||
| Delphinidin | |||
| 760 ± 200 | |||
| 6.3 | |||
|} | |} | ||
=== Inhibiting Compounds === | === Inhibiting Compounds === | ||
{| class="wikitable" | {| class="wikitable" | ||
! | ! Compound | ||
! | ! [[IC50|IC<sub>50</sub>]] value (µM) | ||
|- | |- | ||
| (−)-Catechin gallate | |||
| 2.5 ± 0.03 | |||
|- | |- | ||
| (−)-Gallocatechin gallate | |||
| 5.4 ± 0.04 | |||
|} | |} | ||