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Senolytics: Difference between revisions
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<ref>{{cite web|url=https://newsnetwork.mayoclinic.org/discussion/mayo-researchers-demonstrate-senescent-cell-burden-is-reduced-in-humans-by-senolytic-drugs/|title=Mayo researchers demonstrate senescent cell burden is reduced in humans by senolytic drugs|work=Mayo Clinic|date=18 September 2019|access-date=20 September 2019}}</ref><ref>{{cite web|url=https://www.ebiomedicine.com/article/S2352-3964(19)30591-2/pdf|title=Senolytics decrease senescent cells in humans: Preliminary report from a clinical trial of Dasatinib plus Quercetin in individuals with diabetic kidney disease|work=EBioMedicine|date=20 September 2019|access-date=20 September 2019}}</ref> | <ref>{{cite web|url=https://newsnetwork.mayoclinic.org/discussion/mayo-researchers-demonstrate-senescent-cell-burden-is-reduced-in-humans-by-senolytic-drugs/|title=Mayo researchers demonstrate senescent cell burden is reduced in humans by senolytic drugs|work=Mayo Clinic|date=18 September 2019|access-date=20 September 2019}}</ref><ref>{{cite web|url=https://www.ebiomedicine.com/article/S2352-3964(19)30591-2/pdf|title=Senolytics decrease senescent cells in humans: Preliminary report from a clinical trial of Dasatinib plus Quercetin in individuals with diabetic kidney disease|work=EBioMedicine|date=20 September 2019|access-date=20 September 2019}}</ref> | ||
* 2021: Scientists report alternative approach to [[Senolytics|senolytics]] for removing [[Senescent cells|senescent cells]]: [[Natural killer T cell#Invariant%20NKT%20(iNKT)%20cells|invariant NKT (iNKT) cells]].<ref>{{cite news|title=Scientists find mechanism that eliminates senescent cells|url=https://medicalxpress.com/news/2021-05-scientists-mechanism-senescent-cells.html|access-date=28 June 2021|work=medicalxpress.com|language=en}}</ref><ref>{{cite journal|vauthors=Arora S, Thompson PJ, Wang Y, Bhattacharyya A, Apostolopoulou H, Hatano R, Naikawadi RP, Shah A, Wolters PJ, Koliwad S, Bhattacharya M, Bhushan A|display-authors=6|title=Invariant Natural Killer T cells coordinate removal of senescent cells|language=English|journal=Med|volume=2|issue=8|pages=938–950|date=August 2021|pmid=34617070|pmc=8491998|doi=10.1016/j.medj.2021.04.014|doi-access=free}}</ref> | * 2021: Scientists report alternative approach to [[Senolytics|senolytics]] for removing [[Senescent cells|senescent cells]]: [[Natural killer T cell#Invariant%20NKT%20(iNKT)%20cells|invariant NKT (iNKT) cells]].<ref>{{cite news|title=Scientists find mechanism that eliminates senescent cells|url=https://medicalxpress.com/news/2021-05-scientists-mechanism-senescent-cells.html|access-date=28 June 2021|work=medicalxpress.com|language=en}}</ref><ref>{{cite journal|vauthors=Arora S, Thompson PJ, Wang Y, Bhattacharyya A, Apostolopoulou H, Hatano R, Naikawadi RP, Shah A, Wolters PJ, Koliwad S, Bhattacharya M, Bhushan A|display-authors=6|title=Invariant Natural Killer T cells coordinate removal of senescent cells|language=English|journal=Med|volume=2|issue=8|pages=938–950|date=August 2021|pmid=34617070|pmc=8491998|doi=10.1016/j.medj.2021.04.014|doi-access=free}}</ref> | ||
* 2022: [[Biogerontology|Biomedical gerontologists]] demonstrate a mechanism of anti-aging [[Senolytic|senolytics]], in particular of [[Dasatinib]] plus [[Quercetin]] (D+Q) – an increase [[Klotho (biology)#Effects%20on%20aging|of α-Klotho]] as shown in mice, human cells and in a [[Clinical trial|human trial]].<ref>{{cite news|title=Senolytic drugs boost key protective protein|url=https://newsnetwork.mayoclinic.org/discussion/senolytic-drugs-boost-key-protective-protein/|access-date=19 April 2022|work=Mayo Clinic News Network|date=15 March 2022}}</ | * 2022: [[Biogerontology|Biomedical gerontologists]] demonstrate a mechanism of anti-aging [[Senolytic|senolytics]], in particular of [[Dasatinib]] plus [[Quercetin]] (D+Q) – an increase [[Klotho (biology)#Effects%20on%20aging|of α-Klotho]] as shown in mice, human cells and in a [[Clinical trial|human trial]].<ref>{{cite news|title=Senolytic drugs boost key protective protein|url=https://newsnetwork.mayoclinic.org/discussion/senolytic-drugs-boost-key-protective-protein/|access-date=19 April 2022|work=Mayo Clinic News Network|date=15 March 2022}}</ref>{{pmid|35292270}} | ||
* 2022: Scientists report that some apparently [[Senescent cell|senescent cells]] – which are targeted by anti-aging [[Senolytics|senolytics]] – are required for regeneration, and suggest tailoring senolytics to precisely target harmful senescent cells while leaving the ones involved in regeneration intact.<ref>{{cite news|title=Scientists reappraise the role of 'zombie' cells that anti-aging medicine has sought to eliminate|url=https://medicalxpress.com/news/2022-10-scientists-reappraise-role-zombie-cells.html|access-date=20 November 2022|work=University of San Francisco via medicalxpress.com|language=en}}</ | * 2022: Scientists report that some apparently [[Senescent cell|senescent cells]] – which are targeted by anti-aging [[Senolytics|senolytics]] – are required for regeneration, and suggest tailoring senolytics to precisely target harmful senescent cells while leaving the ones involved in regeneration intact.<ref>{{cite news|title=Scientists reappraise the role of 'zombie' cells that anti-aging medicine has sought to eliminate|url=https://medicalxpress.com/news/2022-10-scientists-reappraise-role-zombie-cells.html|access-date=20 November 2022|work=University of San Francisco via medicalxpress.com|language=en}}</ref>{{pmid|36227993}} | ||
* 2023: First [[Senolytic|senolytics]] discovered using artificial intelligence:<ref>{{cite web|title=AI helps discover three drugs which could fight effects of ageing|date=14 June 2023|work=Sky News|url=https://news.sky.com/story/ai-helps-discover-three-drugs-which-could-fight-effects-of-ageing-12902182}}</ref><ref>{{cite web|title=AI finds drugs that could kill 'zombie cells' behind ageing|url=https://www.thetimes.co.uk/article/ai-finds-drugs-that-could-kill-zombie-cells-behind-ageing-g6929hstl#:~:text=The%20AI%20selected%2021%20compounds,senescent%20drug%20of%20its%20kind|vauthors=Puttic H|date=15 June 2023|work=The Times}}</ref> Teams from the [[University of Edinburgh]] and the [[Massachusetts Institute of Technology]] independently report the discovery of senolytics using [[Artificial intelligence|artificial intelligence]] for screening large chemical libraries. The works reported compounds of comparable efficacy and increased potency than other known senolytics.<ref>{{ | * 2023: First [[Senolytic|senolytics]] discovered using artificial intelligence:<ref>{{cite web|title=AI helps discover three drugs which could fight effects of ageing|date=14 June 2023|work=Sky News|url=https://news.sky.com/story/ai-helps-discover-three-drugs-which-could-fight-effects-of-ageing-12902182}}</ref><ref>{{cite web|title=AI finds drugs that could kill 'zombie cells' behind ageing|url=https://www.thetimes.co.uk/article/ai-finds-drugs-that-could-kill-zombie-cells-behind-ageing-g6929hstl#:~:text=The%20AI%20selected%2021%20compounds,senescent%20drug%20of%20its%20kind|vauthors=Puttic H|date=15 June 2023|work=The Times}}</ref> Teams from the [[University of Edinburgh]] and the [[Massachusetts Institute of Technology]] independently report the discovery of senolytics using [[Artificial intelligence|artificial intelligence]] for screening large chemical libraries. The works reported compounds of comparable efficacy and increased potency than other known senolytics.<ref>{{pmid|37301862}}</ref><ref>{{pmid|37142829}}</ref> | ||
== References == | == References == | ||
<references /> | <references /> | ||
[[Category:Senolytic Compounds|!Senolytics]] | [[Category:Senolytic Compounds|!Senolytics]] | ||