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 == Todo ==
-* 2019: Scientists at the [[Mayo Clinic]] report the first successful use of [[Senolytics|senolytics]], a new class of drug with potential anti-aging benefits, to remove [[Cellular senescence|senescent cells]] from human patients with a kidney disease.
+* 2019: Scientists at the Mayo Clinic report the first successful use of [[Senolytics|senolytics]], a new class of drug with potential anti-aging benefits, to remove [[Senescent Cells|senescent cells]] from human patients with a kidney disease.
 <ref>{{cite web|url=https://newsnetwork.mayoclinic.org/discussion/mayo-researchers-demonstrate-senescent-cell-burden-is-reduced-in-humans-by-senolytic-drugs/|title=Mayo researchers demonstrate senescent cell burden is reduced in humans by senolytic drugs|work=Mayo Clinic|date=18 September 2019|access-date=20 September 2019}}</ref><ref>{{cite web|url=https://www.ebiomedicine.com/article/S2352-3964(19)30591-2/pdf|title=Senolytics decrease senescent cells in humans: Preliminary report from a clinical trial of Dasatinib plus Quercetin in individuals with diabetic kidney disease|work=EBioMedicine|date=20 September 2019|access-date=20 September 2019}}</ref>
-* 2021: Scientists report alternative approach to [[Senolytics|senolytics]] for removing [[Senescent cells|senescent cells]]: [[Natural killer T cell#Invariant%20NKT%20(iNKT)%20cells|invariant NKT (iNKT) cells]].<ref>{{cite news|title=Scientists find mechanism that eliminates senescent cells|url=https://medicalxpress.com/news/2021-05-scientists-mechanism-senescent-cells.html|access-date=28 June 2021|work=medicalxpress.com|language=en}}</ref><ref>{{cite journal|vauthors=Arora S, Thompson PJ, Wang Y, Bhattacharyya A, Apostolopoulou H, Hatano R, Naikawadi RP, Shah A, Wolters PJ, Koliwad S, Bhattacharya M, Bhushan A|display-authors=6|title=Invariant Natural Killer T cells coordinate removal of senescent cells|language=English|journal=Med|volume=2|issue=8|pages=938–950|date=August 2021|pmid=34617070|pmc=8491998|doi=10.1016/j.medj.2021.04.014|doi-access=free}}</ref>
+* 2021: Scientists report alternative approach to [[Senolytics|senolytics]] for removing [[Senescent Cells|senescent cells]]: invariant NKT (iNKT) cells.<ref>{{cite news|title=Scientists find mechanism that eliminates senescent cells|url=https://medicalxpress.com/news/2021-05-scientists-mechanism-senescent-cells.html|access-date=28 June 2021|work=medicalxpress.com|language=en}}</ref><ref>{{cite journal|vauthors=Arora S, Thompson PJ, Wang Y, Bhattacharyya A, Apostolopoulou H, Hatano R, Naikawadi RP, Shah A, Wolters PJ, Koliwad S, Bhattacharya M, Bhushan A|display-authors=6|title=Invariant Natural Killer T cells coordinate removal of senescent cells|language=English|journal=Med|volume=2|issue=8|pages=938–950|date=August 2021|pmid=34617070|pmc=8491998|doi=10.1016/j.medj.2021.04.014|doi-access=free}}</ref>
-* 2022: [[Biogerontology|Biomedical gerontologists]] demonstrate a mechanism of anti-aging [[Senolytic|senolytics]], in particular of [[Dasatinib]] plus [[Quercetin]] (D+Q) – an increase [[Klotho (biology)#Effects%20on%20aging|of α-Klotho]] as shown in mice, human cells and in a [[Clinical trial|human trial]].<ref>{{cite news|title=Senolytic drugs boost key protective protein|url=https://newsnetwork.mayoclinic.org/discussion/senolytic-drugs-boost-key-protective-protein/|access-date=19 April 2022|work=Mayo Clinic News Network|date=15 March 2022}}</ref>{{pmid|35292270}}
+* 2022: [[Biogerontology|Biomedical gerontologists]] demonstrate a mechanism of anti-aging senolytics, in particular of [[Dasatinib]] plus [[Quercetin]] (D+Q) – an increase of α-Klotho as shown in mice, human cells and in a human trial.<ref>{{cite news|title=Senolytic drugs boost key protective protein|url=https://newsnetwork.mayoclinic.org/discussion/senolytic-drugs-boost-key-protective-protein/|access-date=19 April 2022|work=Mayo Clinic News Network|date=15 March 2022}}</ref>{{pmid|35292270}}
-* 2022: Scientists report that some apparently [[Senescent cell|senescent cells]] – which are targeted by anti-aging [[Senolytics|senolytics]] – are required for regeneration, and suggest tailoring senolytics to precisely target harmful senescent cells while leaving the ones involved in regeneration intact.<ref>{{cite news|title=Scientists reappraise the role of 'zombie' cells that anti-aging medicine has sought to eliminate|url=https://medicalxpress.com/news/2022-10-scientists-reappraise-role-zombie-cells.html|access-date=20 November 2022|work=University of San Francisco via medicalxpress.com|language=en}}</ref>{{pmid|36227993}}
+* 2022: Scientists report that some apparently [[Senescent Cells|senescent cells]] – which are targeted by anti-aging [[Senolytics|senolytics]] – are required for regeneration, and suggest tailoring senolytics to precisely target harmful senescent cells while leaving the ones involved in regeneration intact.<ref>{{cite news|title=Scientists reappraise the role of 'zombie' cells that anti-aging medicine has sought to eliminate|url=https://medicalxpress.com/news/2022-10-scientists-reappraise-role-zombie-cells.html|access-date=20 November 2022|work=University of San Francisco via medicalxpress.com|language=en}}</ref>{{pmid|36227993}}
-* 2023: First [[Senolytic|senolytics]] discovered using artificial intelligence:<ref>{{cite web|title=AI helps discover three drugs which could fight effects of ageing|date=14 June 2023|work=Sky News|url=https://news.sky.com/story/ai-helps-discover-three-drugs-which-could-fight-effects-of-ageing-12902182}}</ref><ref>{{cite web|title=AI finds drugs that could kill 'zombie cells' behind ageing|url=https://www.thetimes.co.uk/article/ai-finds-drugs-that-could-kill-zombie-cells-behind-ageing-g6929hstl#:~:text=The%20AI%20selected%2021%20compounds,senescent%20drug%20of%20its%20kind|vauthors=Puttic H|date=15 June 2023|work=The Times}}</ref> Teams from the [[University of Edinburgh]] and the [[Massachusetts Institute of Technology]] independently report the discovery of senolytics using [[Artificial intelligence|artificial intelligence]] for screening large chemical libraries. The works reported compounds of comparable efficacy and increased potency than other known senolytics.<ref>{{pmid|37301862}}</ref><ref>{{pmid|37142829}}</ref>
+* 2023: First senolytics discovered using artificial intelligence:<ref>{{cite web|title=AI helps discover three drugs which could fight effects of ageing|date=14 June 2023|work=Sky News|url=https://news.sky.com/story/ai-helps-discover-three-drugs-which-could-fight-effects-of-ageing-12902182}}</ref><ref>{{cite web|title=AI finds drugs that could kill 'zombie cells' behind ageing|url=https://www.thetimes.co.uk/article/ai-finds-drugs-that-could-kill-zombie-cells-behind-ageing-g6929hstl#:~:text=The%20AI%20selected%2021%20compounds,senescent%20drug%20of%20its%20kind|vauthors=Puttic H|date=15 June 2023|work=The Times}}</ref> Teams from the University of Edinburgh and the Massachusetts Institute of Technology independently report the discovery of senolytics using artificial intelligence for screening large chemical libraries. The works reported compounds of comparable efficacy and increased potency than other known senolytics.{{pmid|37301862}}{{pmid|37142829}}
 == References ==
 <references />
 [[Category:Senolytic Compounds|!Senolytics]]