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! Hallmark | ! Hallmark | ||
! Description | ! Description | ||
! | !Category | ||
!Level | |||
|- | |- | ||
| '''Genomic instability''' | | '''Genomic instability''' | ||
| Accumulation of DNA damage over time leading to cellular dysfunction. | | Accumulation of DNA damage over time leading to cellular dysfunction. | ||
| rowspan=" | | rowspan="5" |'''Primary Hallmarks''' | ||
(causes damage) | (causes damage) | ||
| rowspan="6" |Molecular | |||
|- | |- | ||
| '''Telomere attrition''' | | '''Telomere attrition''' | ||
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|'''Compromised autophagy''' | |'''Compromised autophagy''' | ||
|Impaired cellular maintenance through the consumption of own components. | |Impaired cellular maintenance through the consumption of own components. | ||
| rowspan="4" |'''Antagonistic Hallmarks''' | |||
(responses to damage) | |||
|- | |- | ||
|'''Deregulated nutrient sensing''' | |'''Deregulated nutrient sensing''' | ||
| Alterations in nutrient sensing pathways affecting metabolism and aging. | | Alterations in nutrient sensing pathways affecting metabolism and aging. | ||
| rowspan=" | | rowspan="8" |Cellular & Organismal | ||
|- | |- | ||
|'''Mitochondrial dysfunction''' | |'''Mitochondrial dysfunction''' |