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Hallmarks of Aging: Difference between revisions
→The 14 Hallmarks of Aging (2022)
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To address this, a symposium titled “New Hallmarks of Ageing” was held in Copenhagen on March 2022, where leading experts gathered to discuss potential additions and recontextualizations of these aging hallmarks. The symposium highlighted the critical need for an expanded, inclusive paradigm that encompasses newly identified processes contributing to aging. The discussions suggested the integration of five additional hallmarks such as compromised autophagy, dysregulation in RNA splicing, inflammation, loss of cytoskeleton integrity, and disturbance of the microbiome. These potential new hallmarks, along with the original nine, underscore a more comprehensive understanding of the aging process, acknowledging its multifaceted nature and its profound implications for human health and longevity.{{pmid|36040386}} | To address this, a symposium titled “New Hallmarks of Ageing” was held in Copenhagen on March 2022, where leading experts gathered to discuss potential additions and recontextualizations of these aging hallmarks. The symposium highlighted the critical need for an expanded, inclusive paradigm that encompasses newly identified processes contributing to aging. The discussions suggested the integration of five additional hallmarks such as compromised autophagy, dysregulation in RNA splicing, inflammation, loss of cytoskeleton integrity, and disturbance of the microbiome. These potential new hallmarks, along with the original nine, underscore a more comprehensive understanding of the aging process, acknowledging its multifaceted nature and its profound implications for human health and longevity.{{pmid|36040386}} | ||
{| class="wikitable" | {| class="wikitable" | ||
!Level | |||
! | ! | ||
! Hallmark | ! Hallmark | ||
! Description | ! Description | ||
!Category | !Category | ||
|- | |- | ||
| rowspan="6" |'''Molecular''' | |||
'''Level''' | |||
| style="text-align:center;" |[[File:DNA Structure+Key+Labelled.pn NoBB.png|frameless|76x76px]] | | style="text-align:center;" |[[File:DNA Structure+Key+Labelled.pn NoBB.png|frameless|76x76px]] | ||
| style="background-color:hsla(180, 100%, 75%);" |'''Genomic instability''' | | style="background-color:hsla(180, 100%, 75%);" |'''Genomic instability''' | ||
| Line 76: | Line 78: | ||
| rowspan="5" |'''Primary Hallmarks''' | | rowspan="5" |'''Primary Hallmarks''' | ||
(causes damage) | (causes damage) | ||
|- | |- | ||
| style="text-align:center;" |[[File:Telomeres transparent.png|frameless|88x88px]] | | style="text-align:center;" |[[File:Telomeres transparent.png|frameless|88x88px]] | ||
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(responses to damage) | (responses to damage) | ||
|- | |- | ||
| rowspan="8" |'''Cellular &''' | |||
'''Organismal''' | |||
'''Level''' | |||
| style="text-align:center;" |[[File:Aiga restaurant knife-fork crossed.png|frameless|75x75px]] | | style="text-align:center;" |[[File:Aiga restaurant knife-fork crossed.png|frameless|75x75px]] | ||
| style="background-color:hsla(0, 100%, 75%);" |'''Deregulated nutrient sensing''' | | style="background-color:hsla(0, 100%, 75%);" |'''Deregulated nutrient sensing''' | ||
| style="background-color:hsla(0, 100%, 75%);" | Alterations in nutrient sensing pathways affecting metabolism and aging. | | style="background-color:hsla(0, 100%, 75%);" | Alterations in nutrient sensing pathways affecting metabolism and aging. | ||
|- | |- | ||
| style="text-align:center;" |[[File:Mitochondrion mini.svg|frameless|92x92px]] | | style="text-align:center;" |[[File:Mitochondrion mini.svg|frameless|92x92px]] | ||