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Hallmarks of Aging: Difference between revisions
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These potential new hallmarks, along with the original nine, underscore a more comprehensive understanding of the aging process, acknowledging its multifaceted nature and its profound implications for human health and longevity.{{pmid|36040386}} | These potential new hallmarks, along with the original nine, underscore a more comprehensive understanding of the aging process, acknowledging its multifaceted nature and its profound implications for human health and longevity.{{pmid|36040386}} | ||
=== The Twelve Hallmarks of Aging (2023) === | |||
{| class="wikitable" | {| class="wikitable" | ||
!Level | !Level | ||
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|- | |- | ||
| style="text-align:center; background-color:hsla(210, 100%, 85%);" |[[File:Macro-micro-autophagy.gif|frameless|101x101px]] | | style="text-align:center; background-color:hsla(210, 100%, 85%);" |[[File:Macro-micro-autophagy.gif|frameless|101x101px]] | ||
| style="background-color:hsla(210, 100%, 85%);" |''' | | style="background-color:hsla(210, 100%, 85%);" |'''Disabled autophagy''' | ||
| style="background-color:hsla(210, 100%, 85%);" | Impaired cellular maintenance through the consumption of own components. | | style="background-color:hsla(210, 100%, 85%);" | Impaired cellular maintenance through the consumption of own components. | ||
|2021{{pmid|34563704}} | |2021{{pmid|34563704}} | ||
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| style="text-align:center; background-color:hsla(30, 100%, 85%);" |[[File:Histopathology of acute and chronic inflammation of the gastro-esophageal junction, annotated.jpg|frameless|75x75px]] | | style="text-align:center; background-color:hsla(30, 100%, 85%);" |[[File:Histopathology of acute and chronic inflammation of the gastro-esophageal junction, annotated.jpg|frameless|75x75px]] | ||
| style="background-color:hsla(30, 100%, 85%);" |''' | | style="background-color:hsla(30, 100%, 85%);" |'''Chronic inflammation''' | ||
'''(Inflammaging)''' | '''(Inflammaging)''' | ||
| style="background-color:hsla(30, 100%, 85%);" |Systemic inflammation contributing to aging and related diseases. | | style="background-color:hsla(30, 100%, 85%);" |Systemic inflammation contributing to aging and related diseases. | ||
| | |2023{{pmid|37329949}} | ||
|- | |- | ||
| style="text-align:center; background-color:hsla(30, 100%, 85%);" | | | style="text-align:center; background-color:hsla(30, 100%, 85%);" | | ||
| style="background-color:hsla(30, 100%, 85%);" |'''Altered | | style="background-color:hsla(30, 100%, 85%);" |'''Altered intercellular communication''' | ||
| style="background-color:hsla(30, 100%, 85%);" |Changes in cellular and | | style="background-color:hsla(30, 100%, 85%);" |Changes in cellular communication leading to inflammation and tissue dysfunction. | ||
|2013 | |2013 | ||
|} | |} | ||
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{| class="wikitable" | {| class="wikitable" | ||
|- | |- | ||
| style="text-align:center; background-color:hsla(30, 100%, 85%);" | | | style="text-align:center; background-color:hsla(30, 100%, 85%);" |[[File:Cell structure (13080952404).jpg|frameless|99x99px]] | ||
| style="background-color:hsla(30, 100%, 85%);" |'''Altered | | style="background-color:hsla(30, 100%, 85%);" |'''Altered mechanical properties''' | ||
| style="background-color:hsla(30, 100%, 85%);" |Changes in cellular | | style="background-color:hsla(30, 100%, 85%);" |Changes in cellular and extracellular structure affecting tissue function. | ||
| | |||
|} | |} | ||