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Dose Conversion Between Animals and Human by Allometric Scaling: Difference between revisions
Dose Conversion Between Animals and Human by Allometric Scaling (view source)
Revision as of 11:31, 19 September 2023
, 19 September 2023→Human Equivalent Dose Calculation based on Body Surface Area
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* Do not apply allometric scaling to convert adult doses to kids | * Do not apply allometric scaling to convert adult doses to kids | ||
== | == Correction Factor == | ||
Usually the correction factor (K<sub>m</sub>) is used to estimate the human equivalent dose (HED) for different animal species. K<sub>m</sub> is estimated by dividing the average body weight (kg) of species to its body surface area (m²). For example, the average human body weight is 60 kg, and the body surface area is 1.62 m². Therefore, the K<sub>m</sub> factor for human is calculated by dividing 60 by 1.62, which is 37. As the K<sub>m</sub> factor for each species is constant, the K<sub>m</sub> ratio is used to simplify calculations. | Usually the correction factor (K<sub>m</sub>) is used to estimate the human equivalent dose (HED) for different animal species. K<sub>m</sub> is estimated by dividing the average body weight (kg) of species to its body surface area (m²). For example, the average human body weight is 60 kg, and the body surface area is 1.62 m². Therefore, the K<sub>m</sub> factor for human is calculated by dividing 60 by 1.62, which is 37. As the K<sub>m</sub> factor for each species is constant, the K<sub>m</sub> ratio is used to simplify calculations. | ||
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== Human Equivalent Dose Calculation == | |||
The HED can be calculated by dividing the animal equivalent dose (AED) by the K<sub>m</sub> ratio. The unit of HED and AED is mg/kg. | The HED can be calculated by dividing the animal equivalent dose (AED) by the K<sub>m</sub> ratio. The unit of HED and AED is mg/kg. | ||