2,851
edits
Cellular Senescence: Difference between revisions
→Accumulation with Age
| Line 47: | Line 47: | ||
# '''Environmental and Lifestyle Factors''': Repeated exposure to stressors like ultraviolet radiation, toxins, or an unhealthy lifestyle can further accelerate the accumulation of senescent cells during these years. | # '''Environmental and Lifestyle Factors''': Repeated exposure to stressors like ultraviolet radiation, toxins, or an unhealthy lifestyle can further accelerate the accumulation of senescent cells during these years. | ||
Contrary to the intuitive expectation that senescent cells would continue to accumulate | Contrary to the intuitive expectation that senescent cells would continue to accumulate exponentialy, research has shown that the growth rate declines in advanced age: | ||
# '''Depleted Stem Cell Pools''': With age, the body's pool of stem cells, responsible for tissue regeneration and repair, diminishes. Since there are fewer actively dividing cells in very elderly individuals, there may be fewer cells to enter a senescent state. | # '''Depleted Stem Cell Pools''': With age, the body's pool of stem cells, responsible for tissue regeneration and repair, diminishes. Since there are fewer actively dividing cells in very elderly individuals, there may be fewer cells to enter a senescent state. | ||
| Line 53: | Line 53: | ||
# '''Tissue Atrophy and Reduced Cellularity''': Some tissues lose cell density with advanced age, potentially contributing to the reduced absolute numbers of senescent cells. | # '''Tissue Atrophy and Reduced Cellularity''': Some tissues lose cell density with advanced age, potentially contributing to the reduced absolute numbers of senescent cells. | ||
It's essential to understand that the presence and accumulation of senescent cells in tissues are associated with age-related diseases and dysfunctions. Even if the absolute number stabilizes or slows in its increase, the detrimental effects of these cells, especially through SASP, can have significant impacts on tissue function and overall health. | |||
== Implications for Age-Related Diseases == | == Implications for Age-Related Diseases == | ||