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Cellular Senescence: Difference between revisions
→Accumulation with Age
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# '''Environmental and Lifestyle Factors''': Repeated exposure to stressors like ultraviolet radiation, toxins, or an unhealthy lifestyle can further accelerate the accumulation of senescent cells during these years. | # '''Environmental and Lifestyle Factors''': Repeated exposure to stressors like ultraviolet radiation, toxins, or an unhealthy lifestyle can further accelerate the accumulation of senescent cells during these years. | ||
However, it's not well-established that the growth rate of senescent cells declines substantially in advanced age. The reasons for a potential stabilization or slowdown include: | |||
# '''Depleted Stem Cell Pools''': With age, the body's pool of stem cells, responsible for tissue regeneration and repair, diminishes. Since there are fewer actively dividing cells in very elderly individuals, there may be fewer cells to enter a senescent state. | # '''Depleted Stem Cell Pools''': With age, the body's pool of stem cells, responsible for tissue regeneration and repair, diminishes. Since there are fewer actively dividing cells in very elderly individuals, there may be fewer cells to enter a senescent state. | ||