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Resveratrol: Difference between revisions
→Trans-Resveratrol
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After consumption, 77-80% of resveratrol gets absorbed into the bloodstream through active transport via the intestinal epithelial cells. Once in the bloodstream, it associates with albumin and lipoproteins. Despite its efficient absorption, resveratrol possesses a short half-life of around 1.5 hours. This is attributed to its rapid absorption in the intestine and subsequent degradation in the liver. A significant amount of ingested resveratrol, approximately 49–61%, is eventually excreted through urine. | After consumption, 77-80% of resveratrol gets absorbed into the bloodstream through active transport via the intestinal epithelial cells. Once in the bloodstream, it associates with albumin and lipoproteins. Despite its efficient absorption, resveratrol possesses a short half-life of around 1.5 hours. This is attributed to its rapid absorption in the intestine and subsequent degradation in the liver. A significant amount of ingested resveratrol, approximately 49–61%, is eventually excreted through urine. | ||
Several factors lead to differences in how individuals respond to RSV intake: | Several factors lead to differences in how individuals respond to RSV intake: <ref name=":0" /> | ||
* '''Gut Microbiota Composition:''' The unique blend of microorganisms in one's gut. | * '''Gut Microbiota Composition:''' The unique blend of microorganisms in one's gut. | ||
* '''Genetic Differences:''' Variations in genes that affect metabolism enzymes (like UGTs and SULTs) and transporters. | * '''Genetic Differences:''' Variations in genes that affect metabolism enzymes (like UGTs and SULTs) and transporters. | ||
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{| class="wikitable mw-collapsible mw-collapsed" style="width: 100%;" | {| class="wikitable mw-collapsible mw-collapsed" style="width: 100%;" | ||
|+Reported resveratrol plasma concentration in humans after repeated doses of resveratrol (studies after 2010). <ref>https://www.mdpi.com/2072-6643/11/1/143</ref> | |+Reported resveratrol plasma concentration in humans after repeated doses of resveratrol (studies after 2010). <ref name=":0">https://www.mdpi.com/2072-6643/11/1/143</ref> | ||
!Number of Participants, Characteristics, Study Type | !Number of Participants, Characteristics, Study Type | ||
!Dose<br>(mg/day) | !Dose<br>(mg/day) | ||