Resveratrol: Difference between revisions

Resveratrol (view source)

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 === Trans-Resveratrol ===
-Trans-resveratrol unfortunately suffers from '''poor bioavailability''' and '''water solubility'''. Its solubility in water is less than 0.05 mg/ml. Studies have indicated varying plasma concentrations post-consumption: <ref>https://www.researchgate.net/publication/331424725_Health_benefits_of_resveratrol_administration</ref>
+Trans-resveratrol unfortunately suffers from '''poor bioavailability''' and '''water solubility'''. Its solubility in water is less than 0.05 mg/ml. Studies have indicated varying plasma concentrations after repeated doses of resveratrol:
-* A 25 mg intake of resveratrol resulted in plasma concentrations below 10 ng/ml.
-* A significantly larger dose of 5000 mg led to plasma concentrations of 500 ng/ml.
-* Consuming 500 mg of resveratrol in tablet form produced plasma concentrations of approximately 70 ng/ml.
-After consumption, 77-80% of resveratrol gets absorbed into the bloodstream through active transport via the intestinal epithelial cells. Once in the bloodstream, it associates with albumin and lipoproteins. Despite its efficient absorption, resveratrol possesses a short half-life of around 1.5 hours. This is attributed to its rapid absorption in the intestine and subsequent degradation in the liver. A significant amount of ingested resveratrol, approximately 49–61%, is eventually excreted through urine.
-Several factors lead to differences in how individuals respond to RSV intake: <ref name=":0" />
-* '''Gut Microbiota Composition:''' The unique blend of microorganisms in one's gut.
-* '''Genetic Differences:''' Variations in genes that affect metabolism enzymes (like UGTs and SULTs) and transporters.
-* '''Ethnicity & Geography:''' People from different ethnic backgrounds or geographical locations may metabolize RSV differently.
-* '''Lifestyle & Diet:''' Personal habits and food choices can influence RSV processing.
-* '''Natural Variation:''' Humans naturally vary, leading to different responses to RSV.
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+After consumption, 77-80% of resveratrol gets absorbed into the bloodstream through active transport via the intestinal epithelial cells. Once in the bloodstream, it associates with albumin and lipoproteins. Despite its efficient absorption, resveratrol possesses a short half-life of around 1.5 hours. This is attributed to its rapid absorption in the intestine and subsequent degradation in the liver. A significant amount of ingested resveratrol, approximately 49–61%, is eventually excreted through urine. <ref>https://www.researchgate.net/publication/331424725_Health_benefits_of_resveratrol_administration</ref>
+Several factors lead to differences in how individuals respond to RSV intake: <ref name=":0" />
+* '''Gut Microbiota Composition:''' The unique blend of microorganisms in one's gut.
+* '''Genetic Differences:''' Variations in genes that affect metabolism enzymes (like UGTs and SULTs) and transporters.
+* '''Ethnicity & Geography:''' People from different ethnic backgrounds or geographical locations may metabolize RSV differently.
+* '''Lifestyle & Diet:''' Personal habits and food choices can influence RSV processing.
+* '''Natural Variation:''' Humans naturally vary, leading to different responses to RSV.
 === Micronized Resveratrol ===