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Resveratrol: Difference between revisions
→Formulations and Bioavailability
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After consumption, 77-80% of resveratrol gets absorbed into the bloodstream through active transport via the intestinal epithelial cells. Once in the bloodstream, it associates with albumin and lipoproteins. Despite its efficient absorption, resveratrol possesses a short half-life of around 1.5 hours. This is attributed to its rapid absorption in the intestine and subsequent degradation in the liver. A significant amount of ingested resveratrol, approximately 49–61%, is eventually excreted through urine. <ref>https://www.researchgate.net/publication/331424725_Health_benefits_of_resveratrol_administration</ref> | After consumption, 77-80% of resveratrol gets absorbed into the bloodstream through active transport via the intestinal epithelial cells. Once in the bloodstream, it associates with albumin and lipoproteins. Despite its efficient absorption, resveratrol possesses a short half-life of around 1.5 hours. This is attributed to its rapid absorption in the intestine and subsequent degradation in the liver. A significant amount of ingested resveratrol, approximately 49–61%, is eventually excreted through urine. <ref>https://www.researchgate.net/publication/331424725_Health_benefits_of_resveratrol_administration</ref> | ||
Several factors lead to differences in how individuals respond to | Several factors lead to differences in how individuals respond to resveratrol intake: <ref name=":0" /> | ||
* '''Gut Microbiota Composition:''' The unique blend of microorganisms in one's gut. | * '''Gut Microbiota Composition:''' The unique blend of microorganisms in one's gut. | ||
* '''Genetic Differences:''' Variations in genes that affect metabolism enzymes (like UGTs and SULTs) and transporters. | * '''Genetic Differences:''' Variations in genes that affect metabolism enzymes (like UGTs and SULTs) and transporters. | ||
* '''Ethnicity & Geography:''' People from different ethnic backgrounds or geographical locations may metabolize | * '''Ethnicity & Geography:''' People from different ethnic backgrounds or geographical locations may metabolize resveratrol differently. | ||
* '''Lifestyle & Diet:''' Personal habits and food choices can influence | * '''Lifestyle & Diet:''' Personal habits and food choices can influence resveratrol processing. | ||
* '''Natural Variation:''' Humans naturally vary, leading to different responses to | * '''Natural Variation:''' Humans naturally vary, leading to different responses to resveratrol . | ||
=== Micronized Resveratrol === | === Micronized Resveratrol === | ||