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SIRT1: Difference between revisions
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'''SIRT1''' is one of the seven mammalian [[Sirtuins|sirtuins]], a family of proteins critical to cellular regulation and longevity. Sirtuins, in general, are known for their role in extending lifespan and improving health. SIRT1 is particularly noteworthy due to its extensive involvement in cellular processes that are directly linked to the aging process, including cellular metabolism, inflammation, stress resistance, and survival. | '''SIRT1''' is one of the seven mammalian [[Sirtuins|sirtuins]], a family of proteins critical to cellular regulation and longevity. Sirtuins, in general, are known for their role in extending lifespan and improving health. SIRT1 is particularly noteworthy due to its extensive involvement in cellular processes that are directly linked to the aging process, including cellular metabolism, inflammation, stress resistance, and survival. | ||
Research has demonstrated that overexpression of SIRT1 in mice models leads to extended lifespan and delayed onset of age-related diseases, including neurodegenerative conditions, cardiovascular diseases, and metabolic disorders. Caloric restriction, a well-known lifespan-extending intervention, has been shown to activate SIRT1, suggesting a potential mechanism by which reduced calorie intake promotes longevity. | Research has demonstrated that overexpression of SIRT1 in mice models leads to extended lifespan and delayed onset of age-related diseases, including neurodegenerative conditions, cardiovascular diseases, and metabolic disorders. Caloric restriction, a well-known lifespan-extending intervention, has been shown to activate SIRT1, suggesting a potential mechanism by which reduced calorie intake promotes longevity. Recent studies have also indicated a potential link between SIRT1 and improved vascular function, particularly through Nitrate-Mediated Vasodilation (NMD), a process vital for cardiovascular health and longevity. | ||
= Function and Mechanism = | = Function and Mechanism = | ||
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==== Inflammation Regulation ==== | ==== Inflammation Regulation ==== | ||
By deacetylating nuclear factor-kappa B (NF-κB), a key regulator of inflammatory responses, SIRT1 modulates inflammation within cells, reducing the likelihood of chronic inflammation, a known contributor to aging and age-related diseases. | By deacetylating nuclear factor-kappa B (NF-κB), a key regulator of inflammatory responses, SIRT1 modulates inflammation within cells, reducing the likelihood of chronic inflammation, a known contributor to aging and age-related diseases. | ||
==== Vascular Function ==== | |||
Emerging research suggests that SIRT1 may play a role in promoting vascular health through mechanisms that could include the enhancement of Nitrate-Mediated Vasodilation (NMD). NMD, essential for cardiovascular health, involves the dilation of blood vessels facilitated by dietary nitrates, which are converted to nitric oxide in the body. This process is crucial for maintaining proper blood flow and blood pressure, both of which are fundamental to overall health and longevity. | |||
== Activation of SIRT1 == | == Activation of SIRT1 == | ||