Dose Conversion Between Animals and Human by Allometric Scaling: Difference between revisions
Dose Conversion Between Animals and Human by Allometric Scaling (view source)
Revision as of 09:23, 11 September 2023
, 11 September 2023→Human Equivalent Dose Calculation based on Body Surface Area
(Created page with "Safe and effective drug dosing is necessary, regardless of its purpose of administration. Allometric scaling is an empirical approach where the exchange of drug dose is based...") |
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== Human Equivalent Dose Calculation based on Body Surface Area == | == Human Equivalent Dose Calculation based on Body Surface Area == | ||
Usually the correction factor (K<sub>m</sub>) is used to estimate the human equivalent does (HED) for different animal species. | Usually the correction factor (K<sub>m</sub>) is used to estimate the human equivalent does (HED) for different animal species. K<sub>m</sub> is estimated by dividing the average body weight (kg) of species to its body surface area (m²). For example, the average human body weight is 60 kg, and the body surface area is 1.62 m². Therefore, the K<sub>m</sub> factor for human is calculated by dividing 60 by 1.62, which is 37. As the K<sub>m</sub> factor for each species is constant, the K<sub>m</sub> ratio is used to simplify calculations. | ||
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|+Human equivalent dose calculation based on body surface area | |+Human equivalent dose calculation based on body surface area | ||