Spermidine: Difference between revisions

Spermidine (view source)

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 == Bioavailability ==
-In a [[Randomized Controlled Trial|randomized controlled trail]] <ref>https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10143675/</ref> 15 mg/d of spermidine was administered orally in 12 healthy volunteers for 5 days. When spermidine is taken orally as a supplement, it gets converted into another compound called spermine before it enters the bloodstream. This conversion happens presystemically, meaning it occurs before spermidine gets into the systemic circulation. This process affects the bioavailability of spermidine, which is a term used to describe how much of a substance is absorbed and used by the body.
+In a [[Randomized Controlled Trial|randomized controlled trail]] <ref>https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10143675/</ref> 15 mg/d of spermidine was administered orally in 12 healthy volunteers for 5 days and the blood levels of spermidine and two related compounds, spermine and putrescine, were measured. Only spermine blood levels increased significantly, but no effect on spermidine or putrescine could be detected. That suggests, when spermidine is taken orally as a supplement, it gets converted into spermine before it enters the bloodstream. This conversion happens presystemically, meaning it occurs before spermidine gets into the systemic circulation. This suggest that the bioavailability of spermidine, in its original form, might be low or perhaps altered, but the compound is still bioavailable in a different form (as spermine) which then has systemic effects.
-In simple terms, when you take spermidine, not all of it stays as spermidine by the time it reaches your blood. Instead, it changes into spermine, which then circulates in your blood. This is important because it can affect how spermidine supplements work in the body, and it suggests that the benefits of spermidine might actually be due to spermine.
+The study also found that a daily dose of 15 mg of spermidine was needed to see a significant increase in spermine levels in the blood. Lower doses like 0.9-1.2 mg of spermidine per day didn't show changes in blood levels of spermidine, spermine or putrescine. This suggests that there's a certain amount of spermidine you need to take to see an effect.
-The study also found that a daily dose of 15 mg of spermidine was needed to see a significant increase in spermine levels in the blood. Lower doses like 0.9-1.2 mg of spermidine per day didn't show changes in blood levels of spermidine, spermine, or another related compound, putrescine. This suggests that there's a certain amount of spermidine you need to take to see an effect, and the bioavailability of spermidine might be different at lower doses.
-Additionally, the study showed that spermidine supplementation did not affect the levels of spermidine or other related compounds in the saliva, indicating that oral spermidine supplementation at a dose of 15 mg/d doesn't seem to have an effect on salivary polyamine concentrations.
-In summary, the bioavailability of spermidine, or how well it is absorbed and utilized by the body, is influenced by its conversion to spermine, and the dose of spermidine taken. This information is crucial for understanding how spermidine supplements might work in the body and for determining the right dose to use in future research and clinical applications.
 == Safety and Dosage ==