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Spermidine: Difference between revisions
→Spermidine and Longevity
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==Spermidine and Longevity== | ==Spermidine and Longevity== | ||
Research has identified a significant correlation between the exogenous supplementation of spermidine and increased lifespan in several model organisms such as yeast, worms, flies, and mice. The longevity-promoting properties of spermidine are primarily attributed to its role in inducing autophagy. | Research has identified a significant correlation between the exogenous supplementation of spermidine and increased lifespan in several model organisms such as yeast, worms, flies, and mice. The longevity-promoting properties of spermidine are primarily attributed to its role in inducing autophagy<ref name="Eisenberg2016">Eisenberg T, et al. Cardioprotection and lifespan extension by the natural polyamine spermidine. Nat Med. 2016 Dec;22(12):1428-1438. doi: 10.1038/nm.4222. Epub 2016 Nov 14. PMID: 27841876; PMCID: PMC5806691.</ref>. | ||
=== Autophagy === | === Autophagy === | ||
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=== Cardiovascular Health === | === Cardiovascular Health === | ||
Apart from its role in autophagy, spermidine has been observed to contribute to cardiovascular health. | Apart from its role in autophagy, spermidine has been observed to contribute to cardiovascular health. A significant study demonstrated that oral supplementation of spermidine extended the lifespan of mice and exerted cardioprotective effects, reducing cardiac hypertrophy and preserving diastolic function in old mice. Moreover, spermidine feeding enhanced cardiac autophagy, mitophagy, and mitochondrial respiration, also improving the mechano-elastical properties of cardiomyocytes in vivo. In a model of hypertension-induced congestive heart failure, spermidine feeding reduced systemic blood pressure, prevented cardiac hypertrophy and a decline in diastolic function, thus delaying the progression to heart failure. High levels of dietary spermidine in humans, as assessed from food questionnaires, correlated with reduced blood pressure and a lower incidence of cardiovascular disease<ref name="Eisenberg2016"/>. | ||
== Bioavailability == | == Bioavailability == | ||