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Spermidine: Difference between revisions
→Spermidine and Longevity
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Autophagy is a cellular process involved in the degradation and recycling of obsolete or dysfunctional cellular components. This mechanism is vital for maintaining cellular homeostasis and plays a central role in cell and tissue health. Spermidine's ability to enhance autophagy is of particular interest in the context of aging, as the decline in autophagy has been associated with several age-related pathologies, including neurodegeneration, cardiovascular disease, and cancer. | Autophagy is a cellular process involved in the degradation and recycling of obsolete or dysfunctional cellular components. This mechanism is vital for maintaining cellular homeostasis and plays a central role in cell and tissue health. Spermidine's ability to enhance autophagy is of particular interest in the context of aging, as the decline in autophagy has been associated with several age-related pathologies, including neurodegeneration, cardiovascular disease, and cancer. | ||
Spermidine promotes autophagy through the inhibition of | Spermidine promotes autophagy through the inhibition of a specific enzyme called acetyltransferase EP300. This inhibition leads to a series of cellular events that eventually increase the autophagic processes within the cells. Essentially, spermidine helps in "cleaning up" the cell interiors, which is crucial for cellular maintenance and health, especially as the body ages<ref name="Pietrocola2015">Pietrocola F, et al. Spermidine induces autophagy by inhibiting the acetyltransferase EP300. Cell Death Differ. 2015 Mar;22(3):509-16. doi: 10.1038/cdd.2014.215. Epub 2014 Dec 19. PMID: 25526088; PMCID: PMC4326581.</ref>. | ||
=== Cardiovascular Health === | === Cardiovascular Health === | ||