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=== Dosage === | === Dosage === | ||
The optimal dosage for human health and longevity outcomes remains unclear. In a separate study, 15 mg/day of spermidine was administered orally in 12 healthy volunteers for 5 days. Although spermidine was converted into spermine before entering the bloodstream, a significant increase in spermine levels was only observed at the 15 mg daily dose | The optimal dosage for human health and longevity outcomes remains unclear. In a separate study, 15 mg/day of spermidine was administered orally in 12 healthy volunteers for 5 days. Although spermidine was converted into spermine before entering the bloodstream, a significant increase in spermine levels was only observed at the 15 mg daily dose. Lower doses like 0.9-1.2 mg of spermidine per day didn't show changes in blood levels of spermidine, spermine or putrescine, suggesting that a certain amount of spermidine is necessary to see an effect<ref name=":0" />. | ||
On the supplemental market, in 2023 dosage between 1 and 6 mg/day were advertised. | On the supplemental market, in 2023 dosage between 1 and 6 mg/day were advertised. |