Several factors lead to differences in how individuals respond to resveratrol intake: [1]
- Gut Microbiota Composition: The unique blend of microorganisms in one's gut.
- Genetic Differences: Variations in genes that affect metabolism enzymes (like UGTs and SULTs) and transporters.
- Ethnicity & Geography: People from different ethnic backgrounds or geographical locations may metabolize resveratrol differently.
- Lifestyle & Diet: Personal habits and food choices can influence resveratrol processing.
- Natural Variation: Humans naturally vary, leading to different responses to resveratrol .
- ↑ Springer M & Moco S: Resveratrol and Its Human Metabolites-Effects on Metabolic Health and Obesity.
Nutrients
2019. (PMID 30641865)
[PubMed]
[DOI]
[Full text]
Abstract
Resveratrol is one of the most widely studied polyphenols and it has been assigned a plethora of metabolic effects with potential health benefits. Given its low bioavailability and extensive metabolism, clinical studies using resveratrol have not always replicated in vitro observations. In this review, we discuss human metabolism and biotransformation of resveratrol, and reported molecular mechanisms of action, within the context of metabolic health and obesity. Resveratrol has been described as mimicking caloric restriction, leading to improved exercise performance and insulin sensitivity (increasing energy expenditure), as well as having a body fat-lowering effect by inhibiting adipogenesis, and increasing lipid mobilization in adipose tissue. These multi-organ effects place resveratrol as an anti-obesity bioactive of potential therapeutic use.
