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Resveratrol: Difference between revisions
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|+Reported resveratrol plasma concentration in humans after repeated doses of resveratrol (studies after 2010). | |+Reported resveratrol plasma concentration in humans after repeated doses of resveratrol (studies after 2010). {{#pmid:30641865|pmid30641865}} | ||
!Number of Participants, Characteristics, Study Type | !Number of Participants, Characteristics, Study Type | ||
!Dose<br>(mg/day) | !Dose<br>(mg/day) | ||
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After consumption, 77-80% of resveratrol gets absorbed into the bloodstream through active transport via the intestinal epithelial cells. Once in the bloodstream, it associates with albumin and lipoproteins. Despite its efficient absorption, resveratrol possesses a short half-life of around 1.5 hours. This is attributed to its rapid absorption in the intestine and subsequent degradation in the liver. A significant amount of ingested resveratrol, approximately 49–61%, is eventually excreted through urine. <ref>https://www.researchgate.net/publication/331424725_Health_benefits_of_resveratrol_administration</ref> | After consumption, 77-80% of resveratrol gets absorbed into the bloodstream through active transport via the intestinal epithelial cells. Once in the bloodstream, it associates with albumin and lipoproteins. Despite its efficient absorption, resveratrol possesses a short half-life of around 1.5 hours. This is attributed to its rapid absorption in the intestine and subsequent degradation in the liver. A significant amount of ingested resveratrol, approximately 49–61%, is eventually excreted through urine. <ref>https://www.researchgate.net/publication/331424725_Health_benefits_of_resveratrol_administration</ref> | ||
Several factors lead to differences in how individuals respond to resveratrol intake: | Several factors lead to differences in how individuals respond to resveratrol intake: {{#pmid:30641865|pmid30641865}} | ||
*'''Gut Microbiota Composition:''' The unique blend of microorganisms in one's gut. | *'''Gut Microbiota Composition:''' The unique blend of microorganisms in one's gut. | ||
*'''Genetic Differences:''' Variations in genes that affect metabolism enzymes (like UGTs and SULTs) and transporters. | *'''Genetic Differences:''' Variations in genes that affect metabolism enzymes (like UGTs and SULTs) and transporters. | ||