Resveratrol: Difference between revisions

Line 182: Line 182:
After consumption, 77-80% of resveratrol gets absorbed into the bloodstream through active transport via the intestinal epithelial cells. Once in the bloodstream, it associates with albumin and lipoproteins. Despite its efficient absorption, resveratrol possesses a short half-life of around 1.5 hours. This is attributed to its rapid absorption in the intestine and subsequent degradation in the liver. A significant amount of ingested resveratrol, approximately 49–61%, is eventually excreted through urine. <ref>https://www.researchgate.net/publication/331424725_Health_benefits_of_resveratrol_administration</ref>
After consumption, 77-80% of resveratrol gets absorbed into the bloodstream through active transport via the intestinal epithelial cells. Once in the bloodstream, it associates with albumin and lipoproteins. Despite its efficient absorption, resveratrol possesses a short half-life of around 1.5 hours. This is attributed to its rapid absorption in the intestine and subsequent degradation in the liver. A significant amount of ingested resveratrol, approximately 49–61%, is eventually excreted through urine. <ref>https://www.researchgate.net/publication/331424725_Health_benefits_of_resveratrol_administration</ref>


Several factors lead to differences in how individuals respond to RSV intake: <ref name=":0" />
Several factors lead to differences in how individuals respond to resveratrol intake: <ref name=":0" />
* '''Gut Microbiota Composition:''' The unique blend of microorganisms in one's gut.
* '''Gut Microbiota Composition:''' The unique blend of microorganisms in one's gut.
* '''Genetic Differences:''' Variations in genes that affect metabolism enzymes (like UGTs and SULTs) and transporters.
* '''Genetic Differences:''' Variations in genes that affect metabolism enzymes (like UGTs and SULTs) and transporters.
* '''Ethnicity & Geography:''' People from different ethnic backgrounds or geographical locations may metabolize RSV differently.
* '''Ethnicity & Geography:''' People from different ethnic backgrounds or geographical locations may metabolize resveratrol differently.
* '''Lifestyle & Diet:''' Personal habits and food choices can influence RSV processing.
* '''Lifestyle & Diet:''' Personal habits and food choices can influence resveratrol processing.
* '''Natural Variation:''' Humans naturally vary, leading to different responses to RSV.
* '''Natural Variation:''' Humans naturally vary, leading to different responses to resveratrol .


=== Micronized Resveratrol ===
=== Micronized Resveratrol ===