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Quercetin: Difference between revisions
→Enhancing Bioavailability
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Quercetin, when consumed, undergoes an absorption process primarily in the small intestine. The glycosidic form of quercetin needs to be hydrolyzed by β-glucosidase to its aglycone form before absorption. Once hydrolyzed, it is absorbed through enterocytes via passive diffusion or through active transport mechanisms. The overall absorption of quercetin is estimated to be relatively low, varying between individuals and dependent on dietary matrix and presence of other flavonoids. | Quercetin, when consumed, undergoes an absorption process primarily in the small intestine. The glycosidic form of quercetin needs to be hydrolyzed by β-glucosidase to its aglycone form before absorption. Once hydrolyzed, it is absorbed through enterocytes via passive diffusion or through active transport mechanisms. The overall absorption of quercetin is estimated to be relatively low, varying between individuals and dependent on dietary matrix and presence of other flavonoids. | ||
=='''Enhancing Bioavailability'''== | |||
Due to inherent limitations in bioavailability, several strategies have been explored to enhance the absorption and stability of quercetin. These include the development of various formulations and delivery systems such as: | Due to inherent limitations in bioavailability, several strategies have been explored to enhance the absorption and stability of quercetin. These include the development of various formulations and delivery systems such as: | ||
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| Quercetin Dihydrate || – || Moderate || Synthetic form with two water molecules associated; usually preferred for dietary supplements due to improved solubility. | | Quercetin Dihydrate || – || Moderate || Synthetic form with two water molecules associated; usually preferred for dietary supplements due to improved solubility. | ||
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| Quercetin Phytosomes || Up to 20 times || | | Quercetin Phytosomes || Up to 20 times || Improved || Significantly increases oral bioavailability compared to standard quercetin. | ||
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| Nanoparticle Formulations || Several-fold increase || Variable, generally improved || Includes liposomal encapsulations; increased solubility and cellular uptake. | | Nanoparticle Formulations || Several-fold increase || Variable, generally improved || Includes liposomal encapsulations; increased solubility and cellular uptake. | ||
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| Co-administration with Piperine || Approximately 20% || Low || Inhibits metabolism of quercetin, improving its bioavailability. | | Co-administration with Piperine || Approximately 20% || Low || Inhibits metabolism of quercetin, improving its bioavailability. | ||
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|Liposomal Quercetin | | Liposomal Quercetin || Several-fold increase || Encapsulated in lipid bilayer || Liposomes enhance solubility and cellular uptake. | ||
|Several-fold increase | |||
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|Liposomes enhance solubility and cellular uptake. | |||
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